Concepedia

Computational Specificity Models

Computational Specificity Models is a systematic framework that integrates predictive algorithms and bioinformatics analyses to quantify and minimize off-target effects in genome editing by modeling the binding affinity and cleavage activity of nucleases across non-target genomic sites.

37

Publications

2.4K

Citations

183

Authors

82

Institutions

Publications per year

2017–2026

21

Parents

Publications

37

Predicting sites of ADAR editing in double-stranded RNA

Julie M. Eggington, Tom Greene, Brenda Bass · Nature Communications · 2011 · 405 citations · Full text

, , +14

KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites

Haidong Huang, T.-Y. Lee, S.-W. Tzeng et al. · Nucleic Acids Research · 2005 · 327 citations · Full text

, , +13

Prediction Is a Balancing Act: Importance of Sampling Methods to Balance Sensitivity and Specificity of Predictive Models Based on Imbalanced Chemical Data Sets

Priyanka Banerjee, Frederic O. Dehnbostel · Frontiers in Chemistry · 2018 · 196 citations · Full text

, , +13

Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments

Nature Communications · 2020 · 163 citations · Full text

, , +17

Prediction of CircRNA-Disease Associations Using KATZ Model Based on Heterogeneous Networks

Chunyan Fan, Xiujuan Lei, Fang‐Xiang Wu · International Journal of Biological Sciences · 2018 · 155 citations · Full text

, , +17

1–5 of 37

Authors

183

  1. RG
    Raluca Gordân

    Duke University, United States

    3 publications · 92 citations

    3

    h-index

  2. DV
    Dionne Vafeados

    University of Washington, United States

    2 publications · 50 citations

    2

    h-index

  3. IG
    Inna Goreshnik

    University of Washington, United States

    2 publications · 50 citations

    2

    h-index

  4. HK
    Hugh K. Haddox

    University of Washington, United States

    2 publications · 50 citations

    2

    h-index

  5. JC
    James C. Whisstock

    Monash University, Australia

    2 publications · 130 citations

    2

    h-index

1–5 of 183

Institutions

82

  1. Stanford University

    Stanford, United States

    4 h-index

    22 publications

    580 citations

  2. Karolinska Institutet

    Stockholm, Sweden

    3 h-index

    6 publications

    500 citations

  3. Columbia University

    New York, United States

    3 h-index

    8 publications

    286 citations

  4. Duke University

    Durham, United States

    3 h-index

    9 publications

    310 citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    5 publications

    150 citations

  6. University of Oxford

    Oxford, United Kingdom

    2 h-index

    5 publications

    230 citations

  7. Monash University

    Melbourne, Australia

    2 h-index

    8 publications

    520 citations

  8. University of Illinois Urbana-Champaign

    Urbana, United States

    2 h-index

    21 publications

    2.2K citations

1–8 of 82

Venues

  1. Nucleic Acids Research

    5 publications · 450 citations

    5

    h-index

  2. Nature Communications

    5 publications · 640 citations

    4

    h-index

  3. Bioinformatics

    2 publications · 55 citations

    2

    h-index

  4. Current Topics in Medicinal Chemistry

    2 publications · 50 citations

    2

    h-index

  5. PLoS Biology

    2 publications · 96 citations

    2

    h-index

1–5