Kendell Clement

Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

Benjamin P. Kleinstiver, Alexander A. Sousa, Russell T. Walton et al. · Nature Biotechnology · 2019 · 690 citations

Base Editing, Engineered Crispr–cas12a Variants, Engineering +12

Highly efficient therapeutic gene editing of human hematopoietic stem cells

Yuxuan Wu, Jing Zeng, Benjamin P. Roscoe et al. · Nature Medicine · 2019 · 504 citations

Induced Pluripotent Stem Cell, Genome Surgery, Medicine +7

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells

Jing Liao, Rahul Karnik, Hongcang Gu et al. · Nature Genetics · 2015 · 469 citations · Full text

Chromatin, Lineage Plasticity, Developmental Biology +9

An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities

Jason M. Gehrke, Oliver Cervantes, Kendell Clement et al. · Nature Biotechnology · 2018 · 433 citations · Full text

Apobec3a-cas9 Base Editor

Locally Disordered Methylation Forms the Basis of Intratumor Methylome Variation in Chronic Lymphocytic Leukemia

Dan A. Landau, Kendell Clement, Michael J. Ziller et al. · Cancer Cell · 2014 · 405 citations · Full text

Hematological Malignancy, Chromatin, Disordered Methylation Forms +10