Alexander A. Sousa

Search-and-replace genome editing without double-strand breaks or donor DNA

Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis et al. · Nature · 2019 · 4.4K citations · Full text

Genome Surgery, Medicine, Genetics +5

Enhanced proofreading governs CRISPR–Cas9 targeting accuracy

Janice S. Chen, Yavuz S. Dagdas, Benjamin P. Kleinstiver et al. · Nature · 2017 · 1.2K citations · Full text

Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

Benjamin P. Kleinstiver, Alexander A. Sousa, Russell T. Walton et al. · Nature Biotechnology · 2019 · 690 citations

Base Editing, Engineered Crispr–cas12a Variants, Engineering +12

High levels of AAV vector integration into CRISPR-induced DNA breaks

Killian S. Hanlon, Benjamin P. Kleinstiver, Sara P. Garcia et al. · Nature Communications · 2019 · 409 citations · Full text

Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs

Jennifer Listgarten, Michael M. Weinstein, Benjamin P. Kleinstiver et al. · Nature Biomedical Engineering · 2018 · 320 citations · Full text

Off-target Activities, Engineering, Genome Surgery +13