New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones

Abstract

<italic>N</italic>-propyl-5-substituted isoquinolones were identified as mGluR2 PAMs <italic>via</italic> high-throughput screening (HTS). Initial SAR exploration led to the identification of compound <bold>20</bold>.