Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

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Medicine, Pharmacology, Psychiatry +12

A fast method of molecular shape comparison: A simple application of a Gaussian description of molecular shape

Jennifer Grant, M.A. Gallardo, Barry T. Pickup · Journal of Computational Chemistry · 1996 · 509 citations

Natural Sciences, Biochemistry, Biophysics +10

Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (–)-(1 R, 4 S,5 S,6 S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039)

Matthew Fell, Kjell Svensson, Bryan G. Johnson et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 206 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in Mice

Ruggero Galici, Carrie K. Jones, Yi Nong et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 171 citations

Medicine, Neuroscience, Pharmacology +17

Group II mGlu Receptor Activation Suppresses Norepinephrine Release in the Ventral Hippocampus and Locomotor Responses to Acute Ketamine Challenge

Daniel S. Lorrain, Hervé Schaffhauser, Una C. Campbell et al. · Neuropsychopharmacology · 2003 · 94 citations · Full text

Life Sciences, Neurobiology, Neuroscience +9