Concepedia

Structural Scaffold Hopping

Structural Scaffold Hopping is a computational drug discovery strategy that involves the systematic replacement of a core molecular scaffold within a bioactive compound while retaining or enhancing desired pharmacological properties, thereby enabling the exploration of novel chemical space while preserving biological activity.

45

Publications

1.2K

Citations

468

Authors

95

Institutions

Publications per year

2017–2026

31

Parents

Publications

45

Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists

Tomoaki Hasui, Nobuyuki Matsunaga, Taiichi Ora et al. · Journal of Medicinal Chemistry · 2011 · 110 citations · Full text

, , +17

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

Gary Tresadern, José M. Cid, Gregor J. Macdonald et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 73 citations · Full text

, , +16

Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability

Tong Zhao, Qing Meng, Zhuosen Sun et al. · Journal of Medicinal Chemistry · 2020 · 58 citations · Full text

, , +17

Perspective: present pesticide discovery paradigms promote the evolution of resistance – learn from nature and prioritize multi‐target site inhibitor design

Jonathan Gressel · Pest Management Science · 2019 · 57 citations

, , +17

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach

Agnese Chiara Pippione, Alessandro Giraudo, Davide Bonanni et al. · European Journal of Medicinal Chemistry · 2017 · 42 citations · Full text

, , +16

1–5 of 45

Authors

468

  1. XL
    Xinyong Liu

    Shandong University, China

    3 publications · 90 citations

    3

    h-index

  2. FL
    Fengwei Lin

    Shenyang Pharmaceutical University, China

    2 publications · 31 citations

    2

    h-index

  3. TZ
    Tong Zhao

    Shandong University, China

    2 publications · 74 citations

    2

    h-index

  4. VA
    Vincenzo Abbate

    King's College London, United Kingdom

    2 publications · 70 citations

    2

    h-index

  5. SX
    Shujing Xu

    Shandong University, China

    2 publications · 32 citations

    2

    h-index

1–5 of 468

Institutions

95

  1. China Pharmaceutical University

    Nanjing, China

    4 h-index

    10 publications

    311 citations

  2. Shandong University

    Jinan, China

    3 h-index

    36 publications

    954 citations

  3. Southern Medical University

    Guangzhou, China

    3 h-index

    8 publications

    295 citations

  4. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    15 publications

    311 citations

  5. Fudan University

    Shanghai, China

    2 h-index

    20 publications

    335 citations

  6. China Medical University

    Shenyang, China

    2 h-index

    2 publications

    31 citations

  7. Takeda (Japan)

    Osaka, Japan

    2 h-index

    29 publications

    1.9K citations

  8. University of Catania

    Catania, Italy

    2 h-index

    7 publications

    252 citations

1–8 of 95

Venues

  1. Journal of Medicinal Chemistry

    10 publications · 343 citations

    11

    h-index

  2. European Journal of Medicinal Chemistry

    6 publications · 114 citations

    6

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    5 publications · 172 citations

    5

    h-index

  4. ACS Chemical Neuroscience

    2 publications · 29 citations

    2

    h-index

  5. Bioorganic & Medicinal Chemistry

    2 publications · 41 citations

    2

    h-index

1–5