Tong Zhao

Identification of Dihydrofuro[3,4-<i>d</i>]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties

Dongwei Kang, Heng Zhang, Zhao Wang et al. · Journal of Medicinal Chemistry · 2019 · 86 citations · Full text

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles

Boshi Huang, Wen‐Ming Chen, Tong Zhao et al. · Journal of Medicinal Chemistry · 2019 · 76 citations · Full text

Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability

Tong Zhao, Qing Meng, Zhuosen Sun et al. · Journal of Medicinal Chemistry · 2020 · 54 citations · Full text

Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs

Dongwei Kang, Da Feng, Tiziana Ginex et al. · Acta Pharmaceutica Sinica B · 2019 · 50 citations · Full text

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel

Dongwei Kang, Francesc X. Ruiz, Da Feng et al. · Journal of Medicinal Chemistry · 2020 · 46 citations · Full text