Identification of Dihydrofuro[3,4-<i>d</i>]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties

Dongwei Kang, Heng Zhang, Zhao Wang, +16

Journal of Medicinal Chemistry

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles

Boshi Huang, Wen‐Ming Chen, Tong Zhao, +14

Journal of Medicinal Chemistry

Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability

Tong Zhao, Qing Meng, Zhuosen Sun, +10

Journal of Medicinal Chemistry

Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs

Dongwei Kang, Da Feng, Tiziana Ginex, +10

Acta Pharmaceutica Sinica B

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel

Dongwei Kang, Francesc X. Ruiz, Da Feng, +11

Journal of Medicinal Chemistry

First Detection of Multiple Knockdown Resistance (<i>kdr</i>)-Like Mutations in Voltage-Gated Sodium Channel Using Three New Genotyping Methods in<i>Anopheles sinensis</i>From Guangxi Province, China

Wei Tan, Chun X. Li, Zhong M. Wang, +9

Journal of Medical Entomology

The Role of the VPS4A-Exosome Pathway in the Intrinsic Egress Route of a DNA-Binding Anticancer Drug

Vivien Y. Chen, Maria M. Posada, Levi L. Blazer, +2

Pharmaceutical Research

Vps4a-exosome PathwayDrug TargetingMolecular PathwayMolecular BiologyIntrinsic Egress Route +6

Analysis of rare thalassemia genetic variants based on third-generation sequencing

Cuiting Peng, Haixia Zhang, Jun Ren, +9

Scientific Reports

Design, synthesis and biological evaluation of KRASG12C-PROTACs

Xiaoyi Zhang, Tong Zhao, Minghao Sun, +8

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryBioorganic ChemistryBiochemistryNatural SciencesBiological Evaluation +1

Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery

Dongwei Kang, Zhao Wang, Heng Zhang, +17

ACS Medicinal Chemistry Letters