Boshi Huang

Design, Synthesis, and Evaluation of Thiophene[3,2-<i>d</i>]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles

Dongwei Kang, Zengjun Fang, Zhenyu Li et al. · Journal of Medicinal Chemistry · 2016 · 135 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus

Ye Tian, Zhaoqiang Liu, Jinghan Liu et al. · European Journal of Medicinal Chemistry · 2018 · 96 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Structure-Based Optimization of Thiophene[3,2-<i>d</i>]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants

Dongwei Kang, Zengjun Fang, Boshi Huang et al. · Journal of Medicinal Chemistry · 2017 · 91 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: Optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches

Boshi Huang, Cuicui Li, Wen‐Ming Chen et al. · European Journal of Medicinal Chemistry · 2015 · 90 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +15

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles

Boshi Huang, Wen‐Ming Chen, Tong Zhao et al. · Journal of Medicinal Chemistry · 2019 · 77 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17