Concepedia

Scaffold Hopping

Scaffold Hopping is a medicinal chemistry strategy, regarded as a subset of bioisosteric lead optimization, that generates structurally novel analogs by replacing the core molecular scaffold of an active compound with a topologically or electronically distinct framework while preserving essential pharmacophoric features and biological activity.

219

Publications

10K

Citations

1.7K

Authors

393

Institutions

Publications per year

2017–2026

102

Variants

Scaffold-hopping

Parents

Children

Publications

219

“Scaffold-Hopping” by Topological Pharmacophore Search: A Contribution to Virtual Screening

Gisbert Schneider, Werner Neidhart, Thomas Giller et al. · Angewandte Chemie International Edition · 1999 · 691 citations

, , +14

A Shape-Based 3-D Scaffold Hopping Method and Its Application to a Bacterial Protein−Protein Interaction

Thomas S. Rush, Jennifer Grant, Lidia Mosyak et al. · Journal of Medicinal Chemistry · 2005 · 605 citations · Full text

, , +14

Recent Advances in Scaffold Hopping

Ye Hu, Dagmar Stumpfe, Jürgen Bajorath · Journal of Medicinal Chemistry · 2016 · 365 citations · Full text

, , +11

Scaffold hopping by net photochemical carbon deletion of azaarenes

Jisoo Woo, Alec H. Christian, Samantha A. Burgess et al. · Science · 2022 · 262 citations · Full text

, , +17

Quest for the Rings. In Silico Exploration of Ring Universe To Identify Novel Bioactive Heteroaromatic Scaffolds

Peter Ertl, Stephen Jelfs, Jörg Mühlbacher et al. · Journal of Medicinal Chemistry · 2006 · 252 citations

, , +17

1–5 of 219

Authors

1.7K

  1. JB
    Jürgen Bajorath

    University of Bonn, Germany

    10 publications · 640 citations

    10

    h-index

  2. GS
    Gisbert Schneider

    ETH Zurich, Switzerland

    8 publications · 1.1K citations

    8

    h-index

  3. AR
    Antonio Rescifina

    University of Catania, Italy

    4 publications · 150 citations

    4

    h-index

  4. PE
    Peter Ertl

    Novartis (Switzerland), Switzerland

    4 publications · 566 citations

    4

    h-index

  5. CS
    Chunquan Sheng

    Second Military Medical University, China

    4 publications · 180 citations

    4

    h-index

1–5 of 1.7K

Institutions

393

  1. Chinese Academy of Sciences

    Beijing, China

    11 h-index

    89 publications

    2.8K citations

  2. Shanghai Institute of Materia Medica

    Pudong, China

    10 h-index

    82 publications

    2.5K citations

  3. University of Bonn

    Bonn, Germany

    9 h-index

    24 publications

    1.9K citations

  4. Novartis (Switzerland)

    Basel, Switzerland

    6 h-index

    20 publications

    2.1K citations

  5. Novartis Institutes for BioMedical Research

    Basel, Switzerland

    6 h-index

    20 publications

    2.1K citations

  6. University of Chinese Academy of Sciences

    Beijing, China

    5 h-index

    35 publications

    781 citations

  7. AstraZeneca (Sweden)

    Södertälje, Sweden

    5 h-index

    25 publications

    1.3K citations

  8. East China University of Science and Technology

    Shanghai, China

    5 h-index

    39 publications

    2.7K citations

1–8 of 393

Venues

  1. Journal of Medicinal Chemistry

    38 publications · 3K citations

    27

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    33 publications · 924 citations

    20

    h-index

  3. Journal of Chemical Information and Modeling

    JCIM · 20 publications · 796 citations

    17

    h-index

  4. European Journal of Medicinal Chemistry

    24 publications · 607 citations

    16

    h-index

  5. Bioorganic & Medicinal Chemistry

    11 publications · 293 citations

    11

    h-index

1–5