Concepedia

Bioisosterism

Bioisosterism is a rational design strategy in medicinal chemistry that systematically replaces molecular fragments with structurally different but physicochemically similar chemical groups to optimize pharmacological properties while preserving the desired biological activity of a lead compound.

12.4K

Publications

570.4K

Citations

33K

Authors

3.1K

Institutions

Publications per year

2017–2026

703

Parents

Children

Publications

12.4K

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

Ellen M. Sletten, Carolyn R. Bertozzi · Angewandte Chemie International Edition · 2009 · 3.1K citations · Full text

, , +5

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

Nicholas A. Meanwell · Journal of Medicinal Chemistry · 2011 · 2.8K citations · Full text

, , +11

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

Owen W. Griffith, A Meister · Journal of Biological Chemistry · 1979 · 1.7K citations · Full text

, , +13

Oxidation of Pharmaceuticals during Ozonation and Advanced Oxidation Processes

Marc M. Huber, Silvio Canonica, Gun-Young Park et al. · Environmental Science & Technology · 2003 · 1.6K citations · Full text

, , +14

A molecular light switch for DNA: Ru(bpy)2(dppz)2+

Alan E. Friedman, J.‐C. Chambron, Jean Pierre Sauvage et al. · Journal of the American Chemical Society · 1990 · 1.4K citations

, , +5

1–5 of 12.4K

Authors

33K

  1. EJ
    E. J. Corey

    Harvard University, United States

    49 publications · 4.7K citations

    37

    h-index

  2. CD
    Carl Djerassi

    Stanford University, United States

    62 publications · 2.1K citations

    27

    h-index

  3. BM
    Barry M. Trost

    Stanford University, United States

    25 publications · 1.8K citations

    23

    h-index

  4. KF
    Karl Folkers

    The University of Texas at Austin, United States

    42 publications · 2.1K citations

    23

    h-index

  5. HR
    Henry Rapoport

    University of California, Berkeley, United States

    32 publications · 1.4K citations

    21

    h-index

1–5 of 33K

Institutions

3.1K

  1. Centre National de la Recherche Scientifique

    Paris, France

    37 h-index

    339 publications

    14.4K citations

  2. Harvard University

    Cambridge, United States

    31 h-index

    105 publications

    9.3K citations

  3. The University of Tokyo

    Tokyo, Japan

    29 h-index

    209 publications

    9K citations

  4. Kyoto University

    Kyoto, Japan

    28 h-index

    234 publications

    9K citations

  5. National Institutes of Health

    Bethesda, United States

    27 h-index

    152 publications

    7.1K citations

  6. Vanderbilt University

    Nashville, United States

    27 h-index

    121 publications

    6.6K citations

  7. University of Minnesota

    Minneapolis, United States

    26 h-index

    107 publications

    5.4K citations

  8. Purdue University West Lafayette

    West Lafayette, United States

    25 h-index

    120 publications

    5.9K citations

1–8 of 3.1K

Venues

  1. Journal of the American Chemical Society

    JACS · 3.3K publications · 176.1K citations

    159

    h-index

  2. Biochemistry

    654 publications · 42.7K citations

    102

    h-index

  3. The Journal of Organic Chemistry

    JOC · 2.4K publications · 85.9K citations

    96

    h-index

  4. Journal of Medicinal Chemistry

    526 publications · 29.3K citations

    77

    h-index

  5. Angewandte Chemie International Edition

    119 publications · 12.3K citations

    61

    h-index

1–5

See also

Bioisosterism

Core Methods

Applications

Variants

Evaluation