Concepedia

Conformational Restriction

Conformational Restriction is a strategic modification in medicinal chemistry whereby the flexibility of a molecule is reduced by introducing structural constraints, thereby limiting its range of accessible conformations to stabilize a bioactive conformation that enhances potency, selectivity, or metabolic stability.

442

Publications

17.3K

Citations

2.1K

Authors

444

Institutions

Publications per year

2017–2026

29

Variants

Conformational Constraint

Parents

Children

Publications

442

Conformational restrictions of biologically active peptides via amino acid side chain groups

Victor J. Hruby · Life Sciences · 1982 · 399 citations

, , +16

Bioactive Conformation of Luteinizing Hormone-Releasing Hormone: Evidence from a Conformationally Constrained Analog

Roger Freidinger, Daniel F. Veber, Debra S. Perlow et al. · Science · 1980 · 313 citations

, , +16

Conformationally Restricted Aza‐BODIPY: Highly Fluorescent, Stable Near‐Infrared Absorbing Dyes

Weili Zhao, Erick M. Carreira · Chemistry - A European Journal · 2006 · 282 citations · Full text

, , +15

4,4-Difluoro-4-bora-3a,4a-diaza-<i>s</i>-indacene (BODIPY) Dyes Modified for Extended Conjugation and Restricted Bond Rotations

Jiong Chen, Armin Burghart, Agnes Derecskei‐Kovacs et al. · The Journal of Organic Chemistry · 2000 · 273 citations

, , +16

Flexible Molecules with Defined Shape—Conformational Design

Reinhard W. Hoffmann · Angewandte Chemie International Edition in English · 1992 · 229 citations

, , +8

1–5 of 442

Authors

2.1K

  1. SS
    Satoshi Shuto

    Hokkaido University, Japan

    22 publications · 973 citations

    17

    h-index

  2. AM
    Akira Matsuda

    Hokkaido University, Japan

    13 publications · 700 citations

    13

    h-index

  3. VJ
    Victor J. Hruby

    University of Arizona, United States

    9 publications · 663 citations

    9

    h-index

  4. MA
    Mitsuhiro Arisawa

    Hokkaido University, Japan

    8 publications · 248 citations

    8

    h-index

  5. JE
    John E. Macor

    Bristol-Myers Squibb (United States), United States

    6 publications · 106 citations

    6

    h-index

1–5 of 2.1K

Institutions

444

  1. Hokkaido University

    Sapporo, Japan

    18 h-index

    111 publications

    4.9K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    50 publications

    1.5K citations

  3. University of Arizona

    Tucson, United States

    8 h-index

    34 publications

    1.5K citations

  4. United States Military Academy

    West Point, United States

    7 h-index

    36 publications

    2.7K citations

  5. Pfizer (United States)

    New York, United States

    6 h-index

    38 publications

    1.2K citations

  6. Marche Polytechnic University

    Ancona, Italy

    6 h-index

    28 publications

    486 citations

  7. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    6 h-index

    46 publications

    4.2K citations

  8. Bristol-Myers Squibb (United States)

    New York, United States

    6 h-index

    73 publications

    1.7K citations

1–8 of 444

Venues

  1. Journal of Medicinal Chemistry

    87 publications · 3.4K citations

    38

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    41 publications · 1.2K citations

    22

    h-index

  3. Journal of the American Chemical Society

    JACS · 24 publications · 1.7K citations

    21

    h-index

  4. The Journal of Organic Chemistry

    JOC · 33 publications · 1.7K citations

    21

    h-index

  5. Tetrahedron Letters

    28 publications · 778 citations

    17

    h-index

1–5