Concepedia

Conformational Entropy Reduction

Conformational Entropy Reduction is a thermodynamic principle in structural chemistry that refers to the decrease in the number of accessible conformational states of a molecule upon binding or constraint, thereby increasing its binding affinity due to reduced entropic penalty.

91

Publications

4.7K

Citations

414

Authors

184

Institutions

Publications per year

2017–2026

28

Parents

Publications

91

Toward rational protein crystallization: A Web server for the design of crystallizable protein variants

Lukasz Goldschmidt, David R. Cooper, Zygmunt S. Derewenda et al. · Protein Science · 2007 · 284 citations · Full text

, , +15

A physical basis for protein secondary structure

Rajgopal Srinivasan, George D. Rose · Proceedings of the National Academy of Sciences · 1999 · 211 citations · Full text

, , +17

Circular β‐lactamase: stability enhancement by cyclizing the backbone

Hideo Iwaï, Andreas Plückthun · FEBS Letters · 1999 · 192 citations · Full text

, , +17

Protein crystallization by surface entropy reduction: optimization of the SER strategy

David R. Cooper, Tomasz Boczek, Katarzyna Grelewska‐Nowotko et al. · Acta Crystallographica Section D Biological Crystallography · 2007 · 167 citations

, , +16

Empirical free energy calculations of ligand-protein crystallographic complexes. I. Knowledge-based ligand-protein interaction potentials applied to the prediction of human immunodeficiency virus 1 protease binding affinity

Gennady M. Verkhivker, Krzysztof Appelt, Stephan T. Freer et al. · Protein Engineering Design and Selection · 1995 · 162 citations

, , +17

1–5 of 91

Authors

414

  1. WC
    Wei Chen

    University of Science and Technology of China, China

    3 publications · 187 citations

    3

    h-index

  2. ZS
    Zygmunt S. Derewenda

    University of Virginia, United States

    3 publications · 556 citations

    3

    h-index

  3. LL
    Liangbin Li

    University of Science and Technology of China, China

    3 publications · 187 citations

    3

    h-index

  4. GD
    George D. Rose

    Johns Hopkins University, United States

    2 publications · 251 citations

    2

    h-index

  5. FP
    Fan Peng

    University of Science and Technology of China, China

    2 publications · 107 citations

    2

    h-index

1–5 of 414

Institutions

184

  1. Johns Hopkins University

    Baltimore, United States

    4 h-index

    10 publications

    1.3K citations

  2. University of Science and Technology of China

    Hefei, China

    3 h-index

    24 publications

    1.5K citations

  3. University of Virginia

    Charlottesville, United States

    3 h-index

    13 publications

    2.2K citations

  4. Tsinghua University

    Beijing, China

    3 h-index

    18 publications

    523 citations

  5. National Synchrotron Radiation Laboratory

    Hefei, China

    3 h-index

    23 publications

    1.5K citations

  6. University of Cologne

    Cologne, Germany

    2 h-index

    2 publications

    46 citations

  7. University of Freiburg

    Freiburg im Breisgau, Germany

    2 h-index

    5 publications

    283 citations

  8. Fudan University

    Shanghai, China

    2 h-index

    6 publications

    120 citations

1–8 of 184

Venues

  1. The Journal of Chemical Physics

    6 publications · 225 citations

    6

    h-index

  2. Journal of the American Chemical Society

    JACS · 6 publications · 338 citations

    6

    h-index

  3. The Journal of Physical Chemistry B

    6 publications · 143 citations

    6

    h-index

  4. Macromolecules

    4 publications · 152 citations

    4

    h-index

  5. Biophysical Journal

    4 publications · 61 citations

    4

    h-index

1–5