Concepedia

Functional Group Substitution

Functional Group Substitution is a medicinal chemistry design strategy in which a specific functional group in a bioactive molecule is systematically replaced, typically by a bioisosteric group, to modulate physicochemical, pharmacokinetic, or biological properties while preserving the essential molecular framework and target interaction profile.

689

Publications

27.7K

Citations

2.1K

Authors

425

Institutions

Publications per year

2017–2026

52

Variants

Functional Group Bioisosteres

Parents

Children

Publications

689

Electrophilic aromatttic substitution reactions by platinum(II) and palladium(II) chlorides on N,N-dimethylbenzylamines

Arthur C. Cope, Edwin C. Friedrich · Journal of the American Chemical Society · 1968 · 507 citations

, , +11

Catalytic Hydrotrifluoromethylation of Unactivated Alkenes

Satoshi Mizuta, Stefan Verhoog, Keary M. Engle et al. · Journal of the American Chemical Society · 2013 · 427 citations · Full text

, , +8

Fe(III)/NaBH<sub>4</sub>-Mediated Free Radical Hydrofluorination of Unactivated Alkenes

Timothy J. Barker, Dale L. Boger · Journal of the American Chemical Society · 2012 · 345 citations · Full text

, , +14

CF <sub>2</sub> H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH <sub>3</sub> ?

Yossi Zafrani, Gali Sod‐Moriah, Dina Yeffet et al. · Journal of Medicinal Chemistry · 2019 · 336 citations

, , +14

Comprehensive organic functional group transformations

Choice Reviews Online · 1996 · 312 citations

, , +10

1–5 of 689

Authors

2.1K

  1. NK
    Nathan Kornblum

    Purdue University West Lafayette, United States

    10 publications · 438 citations

    10

    h-index

  2. SW
    S. Winstein

    University of California, Los Angeles, United States

    9 publications · 335 citations

    9

    h-index

  3. DJ
    Donald J. Cram

    University of California, Los Angeles, United States

    7 publications · 145 citations

    7

    h-index

  4. FV
    F. Vernon

    University of Salford, United Kingdom

    7 publications · 319 citations

    7

    h-index

  5. GA
    George A. Olah

    University of Southern California, United States

    6 publications · 465 citations

    6

    h-index

1–5 of 2.1K

Institutions

425

  1. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    40 publications

    1.6K citations

  2. Chinese Academy of Sciences

    Beijing, China

    7 h-index

    20 publications

    1.7K citations

  3. University of California, Los Angeles

    Los Angeles, United States

    6 h-index

    17 publications

    556 citations

  4. University of Salford

    Salford, United Kingdom

    6 h-index

    12 publications

    556 citations

  5. Soochow University

    Suzhou, China

    5 h-index

    20 publications

    1.8K citations

  6. Laboratoire de Chimie Organique

    Paris, France

    5 h-index

    17 publications

    545 citations

  7. University of Ferrara

    Ferrara, Italy

    4 h-index

    5 publications

    108 citations

  8. Queen Elizabeth’s Academy

    Mansfield, United Kingdom

    4 h-index

    11 publications

    233 citations

1–8 of 425

Venues

  1. Journal of the American Chemical Society

    JACS · 144 publications · 7.7K citations

    48

    h-index

  2. The Journal of Organic Chemistry

    JOC · 119 publications · 3.5K citations

    33

    h-index

  3. Journal of Medicinal Chemistry

    32 publications · 1.8K citations

    23

    h-index

  4. Tetrahedron

    28 publications · 1K citations

    18

    h-index

  5. Tetrahedron Letters

    28 publications · 948 citations

    18

    h-index

1–5