Concepedia

Classical Bioisosteres

Classical Bioisosteres is a category of bioisosteric replacements characterized by atoms or groups of atoms with similar physical or chemical properties, such as size, electronegativity, and valence, that are used to substitute one another in biologically active compounds to modulate pharmacokinetic or pharmacodynamic properties while maintaining structural similarity.

60

Publications

2.5K

Citations

352

Authors

86

Institutions

Publications per year

2017–2026

8

Parents

Children

Publications

60

Synthesis of Bicyclo[1.1.1]pentane Bioisosteres of Internal Alkynes and <i>para</i>‐Disubstituted Benzenes from [1.1.1]Propellane

Ilya S. Makarov, Cara E. Brocklehurst, Konstantin Karaghiosoff et al. · Angewandte Chemie International Edition · 2017 · 222 citations

, , +15

Antibacterial chalcones––bioisosteric replacement of the 4′-hydroxy group

Simon Feldbæk Nielsen, Thomas Boesen, Mogens Larsen et al. · Bioorganic & Medicinal Chemistry · 2004 · 182 citations

, , +12

Fluoroolefin dipeptide isosteres -II.

Thomas Allmendinger, Eduard Felder, Ernst Hungarbühler · Tetrahedron Letters · 1990 · 123 citations

, , +9

Design, microwave-assisted synthesis, and spasmolytic activity of 2-(alkyloxyaryl)-1H-benzimidazole derivatives as constrained stilbene bioisosteres

Gabriel Navarrete‐Vázquez, Hermenegilda Moreno‐Díaz, Francisco Aguirre‐Crespo et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 105 citations

, , +15

Synthesis and antiprotozoal activity of some 2-(trifluoromethyl)-1H-benzimidazole bioisosteres

Gabriel Navarrete‐Vázquez, Maria de Monserrat Rojano‐Vilchis, Lilián Yépez‐Mulia et al. · European Journal of Medicinal Chemistry · 2005 · 101 citations

, , +10

1–5 of 60

Authors

352

  1. WA
    William A. Kinney

    Johnson & Johnson (United States), United States

    2 publications · 94 citations

    2

    h-index

  2. VK
    Vladimir Kubyshkin

    Technische Universität Berlin, Germany

    2 publications · 72 citations

    2

    h-index

  3. AF
    Arthur F. Ferris

    2 publications · 64 citations

    2

    h-index

  4. IP
    Iryna Pishel

    Enamine (Ukraine), Ukraine

    2 publications · 72 citations

    2

    h-index

  5. GN
    Gabriel Navarrete‐Vázquez

    Universidad Autónoma del Estado de Morelos, Mexico

    2 publications · 206 citations

    2

    h-index

1–5 of 352

Institutions

86

  1. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    3 h-index

    18 publications

    402 citations

  2. CNS Research (United States)

    East Providence, United States

    2 h-index

    24 publications

    1K citations

  3. University of Basel

    Basel, Switzerland

    2 h-index

    3 publications

    112 citations

  4. Universidad Nacional Autónoma de México

    Mexico City, Mexico

    2 h-index

    5 publications

    509 citations

  5. University of Cape Town

    Rondebosch, South Africa

    2 h-index

    14 publications

    322 citations

  6. Novartis (Switzerland)

    Basel, Switzerland

    2 h-index

    5 publications

    813 citations

  7. Novo Nordisk (Denmark)

    Copenhagen, Denmark

    2 h-index

    6 publications

    387 citations

  8. Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar

    Kyiv, Ukraine

    2 h-index

    2 publications

    72 citations

1–8 of 86

Venues

  1. Bioorganic & Medicinal Chemistry Letters

    10 publications · 318 citations

    10

    h-index

  2. The Journal of Organic Chemistry

    JOC · 8 publications · 188 citations

    8

    h-index

  3. Journal of Medicinal Chemistry

    6 publications · 317 citations

    6

    h-index

  4. Bioorganic & Medicinal Chemistry

    6 publications · 373 citations

    6

    h-index

  5. European Journal of Medicinal Chemistry

    5 publications · 274 citations

    5

    h-index

1–5