Concepedia

Hydrogen Atom Replacement

Hydrogen Atom Replacement is a classical bioisostere strategy in medicinal chemistry wherein a hydrogen atom is substituted with a functional group or atom to modulate physicochemical properties, biological activity, or metabolic stability while preserving the core structure of the parent molecule.

138

Publications

6.3K

Citations

522

Authors

198

Institutions

Publications per year

2017–2026

20

Parents

Publications

138

Asparagine and glutamine: using hydrogen atom contacts in the choice of side-chain amide orientation 1 1Edited by J. Thornton

J. Michael Word, Simon C. Lovell, Jane S. Richardson et al. · Journal of Molecular Biology · 1999 · 1.5K citations

, , +14

Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery

Jeroen B. I. Sap, Natan J. W. Straathof, Thomas Knauber et al. · Journal of the American Chemical Society · 2020 · 205 citations · Full text

, , +16

Reductive Dehalogenations of Halobenzoates by Anaerobic Lake Sediment Microorganisms

A. S. Horowitz, Joseph M. Suflita, James M. Tiedje · Applied and Environmental Microbiology · 1983 · 139 citations · Full text

, , +16

THE QUININE-OXIDIZING ENZYME AND LIVER ALDEHYDE OXIDASE

W. Eugene Knox · Journal of Biological Chemistry · 1946 · 131 citations · Full text

, , +11

Novel Fluoroquinolone Antibacterial Agents Containing Oxime-Substituted (Aminomethyl)pyrrolidines:  Synthesis and Antibacterial Activity of 7-(4-(Aminomethyl)-3-(methoxyimino)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro- 4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic Acid (LB20304)<sup>,1</sup>

Chang Yong Hong, Young Kwan Kim, Jay Hyok Chang et al. · Journal of Medicinal Chemistry · 1997 · 127 citations

, , +14

1–5 of 138

Authors

522

  1. JS
    Jane S. Richardson

    Duke University, United States

    2 publications · 1.5K citations

    2

    h-index

  2. CV
    Chivukula V. Sastri

    Indian Institute of Technology Guwahati, India

    2 publications · 71 citations

    2

    h-index

  3. LN
    Loring Nies

    Purdue University West Lafayette, United States

    2 publications · 109 citations

    2

    h-index

  4. JR
    Jens Rickmeier

    Max-Planck-Institut für Kohlenforschung, Germany

    2 publications · 59 citations

    2

    h-index

  5. LH
    Louis Hunter

    2 publications · 41 citations

    2

    h-index

1–5 of 522

Institutions

198

  1. University of Michigan

    Ann Arbor, United States

    5 h-index

    10 publications

    573 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    11 publications

    541 citations

  3. University of Florence

    Florence, Italy

    4 h-index

    22 publications

    656 citations

  4. The University of Osaka

    Osaka, Japan

    3 h-index

    9 publications

    175 citations

  5. University of Chinese Academy of Sciences

    Beijing, China

    3 h-index

    4 publications

    104 citations

  6. Duke University

    Durham, United States

    3 h-index

    10 publications

    6K citations

  7. Babasaheb Bhimrao Ambedkar University

    Lucknow, India

    2 h-index

    2 publications

    71 citations

  8. Chalmers University of Technology

    Gothenburg, Sweden

    2 h-index

    3 publications

    32 citations

1–8 of 198

Venues

  1. Journal of the American Chemical Society

    JACS · 5 publications · 405 citations

    5

    h-index

  2. Journal of Biological Chemistry

    JBC · 5 publications · 315 citations

    5

    h-index

  3. The Journal of Chemical Physics

    4 publications · 178 citations

    4

    h-index

  4. Journal of Medicinal Chemistry

    4 publications · 224 citations

    4

    h-index

  5. Journal of Mass Spectrometry

    JMS · 3 publications · 84 citations

    3

    h-index

1–5