Concepedia

Aromatic Bioisosteres

Aromatic Bioisostere is a bioisosteric replacement in which an aromatic ring system is substituted with another structurally or electronically similar aromatic or non-aromatic moiety to maintain or modulate biological activity while altering physicochemical properties.

258

Publications

9.7K

Citations

1.1K

Authors

288

Institutions

Publications per year

2017–2026

28

Variants

Aromatic Bioisostere

Parents

Children

Publications

258

A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres

Soumitra Agasti, Frédéric Beltran, Emma Pye et al. · Nature Chemistry · 2023 · 306 citations · Full text

, , +13

Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA <sub>2</sub> Inhibitor

Nicholas D. Measom, Kenneth Down, David J. Hirst et al. · ACS Medicinal Chemistry Letters · 2016 · 246 citations · Full text

, , +17

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

Nils Frank, Jeremy Nugent, Bethany R. Shire et al. · Nature · 2022 · 224 citations · Full text

, , +8

Saturated Bioisosteres of <i>ortho</i>‐Substituted Benzenes

Aleksandr Denisenko, Pavel Garbuz, Svitlana V. Shishkina et al. · Angewandte Chemie International Edition · 2020 · 208 citations

, , +14

Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

Benjamin A. Chalmers, Hui Xing, Sevan D. Houston et al. · Angewandte Chemie International Edition · 2016 · 187 citations

, , +13

1–5 of 258

Authors

1.1K

  1. KM
    Kenji Mori

    The University of Tokyo, Japan

    5 publications · 141 citations

    5

    h-index

  2. GP
    G. Paul Savage

    CSIRO Manufacturing, Australia

    4 publications · 418 citations

    4

    h-index

  3. PK
    Pavel K. Mykhailiuk

    Enamine (Ukraine), Ukraine

    4 publications · 351 citations

    4

    h-index

  4. CM
    Craig M. Williams

    The University of Queensland, Australia

    4 publications · 418 citations

    4

    h-index

  5. SD
    Sevan D. Houston

    The University of Queensland, Australia

    4 publications · 418 citations

    4

    h-index

1–5 of 1.1K

Institutions

288

  1. Enamine (Ukraine)

    Kyiv, Ukraine

    5 h-index

    22 publications

    1.7K citations

  2. The University of Queensland

    Brisbane, Australia

    4 h-index

    31 publications

    2.5K citations

  3. University of Naples Federico II

    Naples, Italy

    4 h-index

    20 publications

    828 citations

  4. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    4 h-index

    19 publications

    938 citations

  5. Friedrich-Alexander-Universität Erlangen-Nürnberg

    Erlangen, Germany

    4 h-index

    15 publications

    510 citations

  6. The University of Tokyo

    Tokyo, Japan

    4 h-index

    7 publications

    147 citations

  7. CSIRO Manufacturing

    Canberra, Australia

    4 h-index

    17 publications

    1.8K citations

  8. National Institutes of Health

    Bethesda, United States

    3 h-index

    6 publications

    258 citations

1–8 of 288

Venues

  1. The Journal of Organic Chemistry

    JOC · 24 publications · 911 citations

    19

    h-index

  2. Journal of the American Chemical Society

    JACS · 26 publications · 847 citations

    17

    h-index

  3. Phytochemistry

    20 publications · 796 citations

    17

    h-index

  4. Journal of Medicinal Chemistry

    16 publications · 727 citations

    14

    h-index

  5. Bioorganic & Medicinal Chemistry Letters

    18 publications · 544 citations

    13

    h-index

1–5