Kenneth Down

Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA ₂ Inhibitor

Nicholas D. Measom, Kenneth Down, David J. Hirst et al. · ACS Medicinal Chemistry Letters · 2016 · 234 citations · Full text

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease

Kenneth Down, Augustin Amour, Ian T. Baldwin et al. · Journal of Medicinal Chemistry · 2015 · 130 citations

Asthma, Acute Lung Injury, Pi3kδ Potency +24

Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β)

J.A. Christopher, Paul Bamborough, Catherine M. Alder et al. · Journal of Medicinal Chemistry · 2009 · 30 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +14

Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target

Z.A. Henley, Augustin Amour, Nick Barton et al. · Journal of Medicinal Chemistry · 2019 · 18 citations · Full text

Pharmaceutical Science, Lead Identification, Pharmacotherapy +19

Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase δ through a Deconstruction and Regrowth Approach

Nick Barton, M.A. Convery, Anthony W. J. Cooper et al. · Journal of Medicinal Chemistry · 2018 · 12 citations · Full text

Molecular Biology, Lead Identification, Selective Inhibitors +20