Nick Barton

Discovery of Novel Irreversible Inhibitors of Interleukin (IL)-2-inducible Tyrosine Kinase (Itk) by Targeting Cysteine 442 in the ATP Pocket

John D. Harling, Angela M. Deakin, Sébastien Campos et al. · Journal of Biological Chemistry · 2013 · 32 citations · Full text

Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease

Augustin Amour, Nick Barton, Anthony W. J. Cooper et al. · Journal of Medicinal Chemistry · 2016 · 26 citations · Full text

Pharmaceutical Science, Pharmacotherapy, Novel Oral Series +18

Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target

Z.A. Henley, Augustin Amour, Nick Barton et al. · Journal of Medicinal Chemistry · 2019 · 18 citations · Full text

Pharmaceutical Science, Lead Identification, Pharmacotherapy +19

Antagonism of human<scp>CC</scp>‐chemokine receptor 4 can be achieved through three distinct binding sites on the receptor

Robert J. Slack, Linda Russell, Nick Barton et al. · Pharmacology Research & Perspectives · 2013 · 17 citations · Full text

The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists

Gillian E. Lunniss, Ashley Barnes, Nick Barton et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 15 citations · Full text

Functional Selectivity, Medicine, Neuropeptide Receptor +7