John D. Harling

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

Gareth J. Inman, Francisco José Nicolás, James F. Callahan et al. · Molecular Pharmacology · 2002 · 1.7K citations

Life Sciences, Molecular Biology, Pharmacology +13

Catalytic in vivo protein knockdown by small-molecule PROTACs

Daniel P. Bondeson, Alina Mares, Ian E. Smith et al. · Nature Chemical Biology · 2015 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +9

Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

Nicholas J. Laping, Eugene T. Grygielko, Anil Mathur et al. · Molecular Pharmacology · 2002 · 650 citations

Life Sciences, Molecular Biology, Pharmacology +16

HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins

Dennis L. Buckley, Kanak Raina, Nicole Darricarrère et al. · ACS Chemical Biology · 2015 · 476 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +15

Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)

James F. Callahan, Joelle L. Burgess, James A. Fornwald et al. · Journal of Medicinal Chemistry · 2002 · 309 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11