Anthony W. J. Cooper

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

Marie Pariollaud, Julie Gibbs, Thomas Hopwood et al. · Journal of Clinical Investigation · 2018 · 195 citations · Full text

Inflammatory Lung Disease, Lung Inflammation, Immunology +19

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease

Kenneth Down, Augustin Amour, Ian T. Baldwin et al. · Journal of Medicinal Chemistry · 2015 · 130 citations

Asthma, Acute Lung Injury, Pi3kδ Potency +24

Lead Optimization Using Matched Molecular Pairs: Inclusion of Contextual Information for Enhanced Prediction of hERG Inhibition, Solubility, and Lipophilicity

George Papadatos, M. Alkarouri, Valerie J. Gillet et al. · Journal of Chemical Information and Modeling · 2010 · 130 citations

Pharmaceutical Research, Hit Identification, Molecular Biology +23

Optimized Chemical Probes for REV-ERBα

Ryan P. Trump, Stefano Bresciani, Anthony W. J. Cooper et al. · Journal of Medicinal Chemistry · 2013 · 81 citations · Full text

Molecular Pharmacology, Biochemistry, Functional Selectivity +14

Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors

J. Hamblin, Tony D. Angell, Stuart P. Ballantine et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 71 citations · Full text

Combinatorial Chemistry, Novel Structural Class, Biochemistry +6