Concepedia

Hit Identification

Hit Identification is a drug discovery process in which biologically active compounds are initially detected from screening assays, distinguished from related processes by its focus on the primary recognition of low-affinity or low-potency compounds that demonstrate specific activity against a target of interest.

88

Publications

6.5K

Citations

460

Authors

167

Institutions

Publications per year

2017–2026

29

Parents

Children

Publications

88

Target identification using drug affinity responsive target stability (DARTS)

Brett Lomenick, Rui Hao, Nao Jonai et al. · Proceedings of the National Academy of Sciences · 2009 · 1.1K citations · Full text

, , +13

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

Mei-Chu Lo, Ann Aulabaugh, Guixian Jin et al. · Analytical Biochemistry · 2004 · 685 citations

, , +14

A High-Throughput Screen for Aggregation-Based Inhibition in a Large Compound Library

Brian Y. Feng, Anton Simeonov, Ajit Jadhav et al. · Journal of Medicinal Chemistry · 2007 · 356 citations · Full text

, , +17

HIT: linking herbal active ingredients to targets

Huan Ye, Lin Ye, Hong‐Yo Kang et al. · Nucleic Acids Research · 2010 · 342 citations · Full text

, , +16

Phantom PAINS: Problems with the Utility of Alerts for <u>P</u>an-<u>A</u>ssay <u>IN</u>terference Compound<u>S</u>

Stephen J. Capuzzi, Eugene Muratov, Alexander Tropsha · Journal of Chemical Information and Modeling · 2017 · 251 citations · Full text

, , +14

1–5 of 88

Authors

460

  1. JA
    James A. Wohlschlegel

    University of California, Los Angeles, United States

    2 publications · 1.3K citations

    2

    h-index

  2. JH
    Jing Huang

    University of California, Los Angeles, United States

    2 publications · 1.3K citations

    2

    h-index

  3. YZ
    Yingyao Zhou

    Genomics Institute of the Novartis Research Foundation, United States

    2 publications · 58 citations

    2

    h-index

  4. ZW
    Zhijin Wu

    Brown University, United States

    2 publications · 188 citations

    2

    h-index

  5. JB
    Jürgen Bajorath

    University of Bonn, Germany

    2 publications · 175 citations

    2

    h-index

1–5 of 460

Institutions

167

  1. Novartis (Switzerland)

    Basel, Switzerland

    3 h-index

    19 publications

    1.1K citations

  2. Bayer (Germany)

    Leverkusen, Germany

    2 h-index

    10 publications

    1K citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    2 h-index

    4 publications

    770 citations

  4. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    2 h-index

    15 publications

    1.3K citations

  5. Harvard University

    Cambridge, United States

    2 h-index

    2 publications

    1.1K citations

  6. University of Bonn

    Bonn, Germany

    2 h-index

    5 publications

    470 citations

  7. McGill University

    Montreal, Canada

    2 h-index

    8 publications

    1.3K citations

  8. Alzheimer’s Research UK

    Cambridge, United Kingdom

    2 h-index

    5 publications

    288 citations

1–8 of 167

Venues

  1. SLAS DISCOVERY

    14 publications · 998 citations

    13

    h-index

  2. Journal of Chemical Information and Modeling

    JCIM · 11 publications · 642 citations

    11

    h-index

  3. Journal of Medicinal Chemistry

    4 publications · 634 citations

    4

    h-index

  4. Methods in enzymology on CD-ROM/Methods in enzymology

    Book series · 3 publications · 65 citations

    3

    h-index

  5. Talanta

    2 publications · 86 citations

    2

    h-index

1–5