Concepedia

Hit Confirmation

Hit Confirmation is a methodological process in small-molecule screening that distinguishes true bioactive compounds from false positives by rigorously retesting initial screening hits under controlled conditions to validate their reproducible activity against a biological target.

37

Publications

8.4K

Citations

298

Authors

95

Institutions

Publications per year

2017–2026

7

Parents

Publications

37

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Ophir Shalem, Neville E. Sanjana, Ella Hartenian et al. · Science · 2013 · 5.5K citations · Full text

, , +17

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

Mei-Chu Lo, Ann Aulabaugh, Guixian Jin et al. · Analytical Biochemistry · 2004 · 685 citations

, , +14

Reactive compounds and in vitro false positives in HTS

Gilbert M. Rishton · Drug Discovery Today · 1997 · 354 citations

, , +5

Fueling Open‐Source Drug Discovery: 177 Small‐Molecule Leads against Tuberculosis

Lluís Ballell, Robert H. Bates, Rob J. Young et al. · ChemMedChem · 2013 · 310 citations · Full text

, , +13

Helping Chemists Discover New Antibiotics

Mark A. T. Blaskovich, Johannes Zuegg, Alysha G. Elliott et al. · ACS Infectious Diseases · 2015 · 225 citations

, , +17

1–5 of 37

Authors

298

  1. TD
    Thomas D.Y. Chung

    Sanford Burnham Prebys Medical Discovery Institute, United States

    2 publications · 96 citations

    2

    h-index

  2. KR
    Kevin R. Oldenburg

    Wilmington University, United States

    2 publications · 96 citations

    2

    h-index

  3. JL
    Jamie Longgood

    The University of Texas Southwestern Medical Center, United States

    1 publications · 21 citations

    1

    h-index

  4. DD
    Daniela Divlianska

    Sanford Burnham Prebys Medical Discovery Institute, United States

    1 publications · 28 citations

    1

    h-index

  5. MS
    Mark Slack

    Addenbrooke's Hospital, United Kingdom

    1 publications · 15 citations

    1

    h-index

1–5 of 298

Institutions

95

  1. Institute of Cancer Research

    London, United Kingdom

    2 h-index

    10 publications

    294 citations

  2. University of Washington

    Seattle, United States

    2 h-index

    9 publications

    390 citations

  3. DuPont (United States)

    Wilmington, United States

    2 h-index

    6 publications

    288 citations

  4. Amgen (United States)

    Thousand Oaks, United States

    2 h-index

    2 publications

    396 citations

  5. Wilmington University

    New Castle, United States

    2 h-index

    11 publications

    353 citations

  6. Roche (Switzerland)

    Basel, Switzerland

    1 h-index

    5 publications

    195 citations

  7. University of Minnesota

    Minneapolis, United States

    1 h-index

    10 publications

    280 citations

  8. Temple University

    Philadelphia, United States

    1 h-index

    1 publications

    26 citations

1–8 of 95

Venues

  1. SLAS DISCOVERY

    12 publications · 359 citations

    12

    h-index

  2. MedChemComm

    2 publications · 55 citations

    2

    h-index

  3. ACS Infectious Diseases

    2 publications · 246 citations

    2

    h-index

  4. Journal of Combinatorial Chemistry

    2 publications · 291 citations

    2

    h-index

  5. Journal of Chemical Information and Modeling

    JCIM · 1 publications · 15 citations

    1

    h-index

1–5