Guixian Jin

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

Mei-Chu Lo, Ann Aulabaugh, Guixian Jin et al. · Analytical Biochemistry · 2004 · 675 citations

Drug Target, Engineering, Hit Identification +11

Tumor Cells Chronically Treated with a Trastuzumab–Maytansinoid Antibody–Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments

Frank Loganzo, Xingzhi Tan, Matthew Sung et al. · Molecular Cancer Therapeutics · 2015 · 254 citations

Breast Oncology, Immunology, Adc Resistance +16

Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase

Natasha Emmanuel, Shoba Ragunathan, Qin Shan et al. · Cell Reports · 2017 · 157 citations · Full text

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets

Derek C. Cole, Joseph R. Stock, Rajiv Chopra et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 70 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +11

Synthesis and Structure−Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis

Venkatesan Aranapakam, Jamie M. Davis, G Grosu et al. · Journal of Medicinal Chemistry · 2003 · 69 citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Science +15