Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression.

J A Reed, Frank Loganzo, C R Shea, +7

PubMed

Invasive StageCell SignalingCell Cycle ControlMedicineP16 Gene +12

Tumor Cells Chronically Treated with a Trastuzumab–Maytansinoid Antibody–Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments

Frank Loganzo, Xingzhi Tan, Matthew Sung, +19

Molecular Cancer Therapeutics

Breast OncologyImmunologyAdc ResistanceImmunoeditingImmunotherapeutics +14

Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1)

Matthew Sung, Xingzhi Tan, Bingwen Lu, +12

Molecular Cancer Therapeutics

Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy

L. Nathan Tumey, Manoj B. Charati, Tao He, +9

Bioconjugate Chemistry

Medicinal ChemistryMaleimide-based AdcsBiochemistryAdc PotencyMedicine +12

Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules

Malathi Hari, Frank Loganzo, Tami Annable, +6

Molecular Cancer Therapeutics

CytoskeletonImmunotherapeuticsCancer BiologyCellular PhysiologyTumor Biology +19

HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Frank Loganzo, Carolyn Discafani, Tami Annable, +16

PubMed

Microtubule OrganizationPharmacotherapyTripeptide HemiasterlinTumor BiologyDrug Resistance +16

Discovery of Cytotoxic Dolastatin 10 Analogues with N-Terminal Modifications

Andreas Maderna, Matthew Doroski, Chakrapani Subramanyam, +18

Journal of Medicinal Chemistry

NanotherapeuticsLead AuristatinPeptide ScienceChemical BiologyPharmaceutical Chemistry +18

Potentiation of Apoptosis by Treatment With the Protein Kinase C-Specific Inhibitor Safingol in Mitomycin C-Treated Gastric Cancer Cells

G. K. Schwartz, Adriana Haimovitz‐Friedman, S. K. Dhupar, +7

JNCI Journal of the National Cancer Institute

Targeting Vascular and Avascular Compartments of Tumors with<i>C. novyi-NT</i>and Anti-microtubule Agents

Long H. Dang, Chetan Bettegowda, Nishant Agrawal, +13

Cancer Biology & Therapy

Synthesis, Molecular Editing, and Biological Assessment of the Potent Cytotoxin Leiodermatolide

Damien Mailhol, Jens Willwacher, Nina Kausch‐Busies, +8

Journal of the American Chemical Society

CytoskeletonChemical BiologyPotent Cytotoxin LeiodermatolidePharmaceutical ChemistryTumor Biology +21