Frank Loganzo

Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression.

J A Reed, Frank Loganzo, C R Shea et al. · PubMed · 1995 · 261 citations

Invasive Stage, Cell Signaling, Cell Cycle Control +14

Tumor Cells Chronically Treated with a Trastuzumab–Maytansinoid Antibody–Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments

Frank Loganzo, Xingzhi Tan, Matthew Sung et al. · Molecular Cancer Therapeutics · 2015 · 254 citations

Breast Oncology, Immunology, Adc Resistance +16

Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1)

Matthew Sung, Xingzhi Tan, Bingwen Lu et al. · Molecular Cancer Therapeutics · 2017 · 196 citations

Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy

L. Nathan Tumey, Manoj B. Charati, Tao He et al. · Bioconjugate Chemistry · 2014 · 184 citations

Medicinal Chemistry, Maleimide-based Adcs, Biochemistry +14

Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules

Malathi Hari, Frank Loganzo, Tami Annable et al. · Molecular Cancer Therapeutics · 2006 · 146 citations

Cytoskeleton, Immunotherapeutics, Cancer Biology +21