Manoj B. Charati

Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition

Brendan P. Purcell, David C. Lobb, Manoj B. Charati et al. · Nature Materials · 2014 · 466 citations · Full text

Tissue Engineering, Hydrogels, Biopolymer Gel +7

Tumor Cells Chronically Treated with a Trastuzumab–Maytansinoid Antibody–Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments

Frank Loganzo, Xingzhi Tan, Matthew Sung et al. · Molecular Cancer Therapeutics · 2015 · 254 citations

Breast Oncology, Immunology, Adc Resistance +16

Injectable shear-thinning hydrogels engineered with a self-assembling Dock-and-Lock mechanism

Hoang D. Lu, Manoj B. Charati, Iris L. Kim et al. · Biomaterials · 2011 · 188 citations

Tissue Engineering, Hydrogels, Biopolymer Gel +4

Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy

L. Nathan Tumey, Manoj B. Charati, Tao He et al. · Bioconjugate Chemistry · 2014 · 184 citations

Medicinal Chemistry, Maleimide-based Adcs, Biochemistry +14

A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions

Marc Damelin, Alexander J. Bankovich, Jeffrey Bernstein et al. · Science Translational Medicine · 2017 · 154 citations