Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy

L. Nathan Tumey, Manoj B. Charati, Tao He, +9

Bioconjugate Chemistry

Medicinal ChemistryMaleimide-based AdcsBiochemistryAdc PotencyMedicine +12

Antibacterial Agents That Target Lipid A Biosynthesis in Gram-negative Bacteria

Jane E. Jackman, Carol A. Fierke, L. Nathan Tumey, +5

Journal of Biological Chemistry

Inhibition of the Antibacterial Target UDP-(3-<i>O</i>-acyl)-<i>N</i>-acetylglucosamine Deacetylase (LpxC):  Isoxazoline Zinc Amidase Inhibitors Bearing Diverse Metal Binding Groups

Michael C. Pirrung, L. Nathan Tumey, Christian R.H. Raetz, +6

Journal of Medicinal Chemistry

Bioorganic ChemistryZinc AmidaseGram Negative BacteriaChemical BiologyPharmaceutical Chemistry +14

High-Throughput Catch-and-Release Synthesis of Oxazoline Hydroxamates. Structure−Activity Relationships in Novel Inhibitors of <i>Escherichia </i><i>c</i><i>oli</i> LpxC:  In Vitro Enzyme Inhibition and Antibacterial Properties

Michael C. Pirrung, L. Nathan Tumey, Amanda L. McClerren, +1

Journal of the American Chemical Society

Antibacterial ActivityZinc AmidaseEscherichia ColiAntimicrobial ChemotherapyPharmaceutical Chemistry +18

Where Did the Linker-Payload Go? A Quantitative Investigation on the Destination of the Released Linker-Payload from an Antibody-Drug Conjugate with a Maleimide Linker in Plasma

Cong Wei, Guodong Zhang, Tracey Clark, +5

Analytical Chemistry

Immunocytochemical TechniqueMolecular BiologyAlbumin AdductMedicinal ChemistryImmunochemistry +16

Molecular Validation of LpxC as an Antibacterial Drug Target in <i>Pseudomonas aeruginosa</i>

Khisimuzi Mdluli, Pamela R. Witte, Toni Kline, +9

Antimicrobial Agents and Chemotherapy

Escherichia ColiAntimicrobial ChemotherapyLpxc ActivityBacterial PathogensDrug Resistance +19

The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors

L. Nathan Tumey, David Bom, Bayard R. Huck, +13

Bioorganic & Medicinal Chemistry Letters

Flap Endonuclease 1Medicinal ChemistryN-hydroxy Urea SeriesBioorganic ChemistryPharmaceutical Science +9

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism

L. Nathan Tumey, Carolyn A. Leverett, Beth C. Vetelino, +22

ACS Medicinal Chemistry Letters

Pharmaceutical SciencePharmaceutical ChemistryMedicinal ChemistryBioanalysisImmunochemistry +18

Natural Product Splicing Inhibitors: A New Class of Antibody–Drug Conjugate (ADC) Payloads

Sujiet Puthenveetil, Frank Loganzo, Haiyin He, +19

Bioconjugate Chemistry

Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates

L. Nathan Tumey, Fengping Li, Brian Rago, +16

The AAPS Journal

Drug TargetDrug DesignDrug DiscoveryNatural SciencesMedicine +11