L. Nathan Tumey

Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy

L. Nathan Tumey, Manoj B. Charati, Tao He et al. · Bioconjugate Chemistry · 2014 · 184 citations

Medicinal Chemistry, Maleimide-based Adcs, Biochemistry +14

Antibacterial Agents That Target Lipid A Biosynthesis in Gram-negative Bacteria

Jane E. Jackman, Carol A. Fierke, L. Nathan Tumey et al. · Journal of Biological Chemistry · 2000 · 182 citations · Full text

Inhibition of the Antibacterial Target UDP-(3-<i>O</i>-acyl)-<i>N</i>-acetylglucosamine Deacetylase (LpxC):  Isoxazoline Zinc Amidase Inhibitors Bearing Diverse Metal Binding Groups

Michael C. Pirrung, L. Nathan Tumey, Christian R.H. Raetz et al. · Journal of Medicinal Chemistry · 2002 · 106 citations · Full text

Bioorganic Chemistry, Zinc Amidase, Gram Negative Bacteria +16

High-Throughput Catch-and-Release Synthesis of Oxazoline Hydroxamates. Structure−Activity Relationships in Novel Inhibitors of <i>Escherichia </i><i>c</i><i>oli</i> LpxC:  In Vitro Enzyme Inhibition and Antibacterial Properties

Michael C. Pirrung, L. Nathan Tumey, Amanda L. McClerren et al. · Journal of the American Chemical Society · 2003 · 99 citations

Antibacterial Activity, Zinc Amidase, Escherichia Coli +20

Where Did the Linker-Payload Go? A Quantitative Investigation on the Destination of the Released Linker-Payload from an Antibody-Drug Conjugate with a Maleimide Linker in Plasma

Cong Wei, Guodong Zhang, Tracey Clark et al. · Analytical Chemistry · 2016 · 96 citations

Immunocytochemical Technique, Molecular Biology, Albumin Adduct +18