Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Gina M. DeNicola, Florian A. Karreth, Timothy J. Humpton, +14

Nature

Oncogenic AgentOncogene-induced Nrf2 TranscriptionReactive Oxygen SpecieMedicineCell Biology +3

Where Did the Linker-Payload Go? A Quantitative Investigation on the Destination of the Released Linker-Payload from an Antibody-Drug Conjugate with a Maleimide Linker in Plasma

Cong Wei, Guodong Zhang, Tracey Clark, +5

Analytical Chemistry

Immunocytochemical TechniqueMolecular BiologyAlbumin AdductMedicinal ChemistryImmunochemistry +16

15-oxo-Eicosatetraenoic Acid, a Metabolite of Macrophage 15-Hydroxyprostaglandin Dehydrogenase That Inhibits Endothelial Cell Proliferation

Cong Wei, Peijuan Zhu, Sumit J. Shah, +1

Molecular Pharmacology

Hematopoietic stem cell function requires 12/15-lipoxygenase–dependent fatty acid metabolism

Michelle Kinder, Cong Wei, Suresh G. Shelat, +4

Blood

2017 White Paper on Recent Issues in Bioanalysis: Rise of Hybrid LBA/LCMS Immunogenicity Assays (Part 2: Hybrid LBA/LCMS Biotherapeutics, Biomarkers & Immunogenicity Assays and Regulatory Agencies’ Inputs)

Hendrik Neubert, An Song, Anita Lee, +46

Bioanalysis

Quantitative Conjugated Payload Measurement Using Enzymatic Release of Antibody–Drug Conjugate with Cleavable Linker

Brian Rago, L. Nathan Tumey, Cong Wei, +4

Bioconjugate Chemistry

Quantitative PharmacologyBiomedical EngineeringMedicinal ChemistryBioanalysisImmunochemistry +18

Unconjugated Payload Quantification and Dar Characterization of Antibody–Drug Conjugates Using High-Resolution MS

Leanne Grafmuller, Cong Wei, Ragu Ramanathan, +3

Bioanalysis

LC–MS Challenges in Characterizing and Quantifying Monoclonal Antibodies (mAb) and Antibody-Drug Conjugates (ADC) in Biological Samples

Cong Wei, Dian Su, Jian Wang, +2

Current Pharmacology Reports

MedicineBioanalysisImmunologyLc–ms ChallengesImmunophenotyping +9

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

Jeremy H. Toyn, Kenneth M. Boy, Joseph Raybon, +24

Journal of Pharmacology and Experimental Therapeutics

Calculated Conjugated Payload from Immunoassay and LC–MS Intact Protein Analysis Measurements of Antibody-Drug Conjugate

Brian Rago, Tracey Clark, Lindsay King, +8

Bioanalysis