Joseph R. Stock

Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Scott C. Mayer, Anthony F. Kreft, Boyd L. Harrison et al. · Journal of Medicinal Chemistry · 2008 · 109 citations · Full text

Stable Analogue 10, Alzheimer ’, Social Sciences +19

Acylguanidines as Small-Molecule β-Secretase Inhibitors

Derek C. Cole, Eric S. Manas, Joseph R. Stock et al. · Journal of Medicinal Chemistry · 2006 · 100 citations · Full text

Protein Assembly, Molecular Biology, Amyloid Precursor Protein +20

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets

Derek C. Cole, Joseph R. Stock, Rajiv Chopra et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 70 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +11

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism

L. Nathan Tumey, Carolyn A. Leverett, Beth C. Vetelino et al. · ACS Medicinal Chemistry Letters · 2016 · 70 citations · Full text

Pharmaceutical Science, Pharmaceutical Chemistry, Medicinal Chemistry +20

Discovery of N₁-(6-Chloroimidazo[2,1-<i>b</i>][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT₆Receptor Agonist

Derek C. Cole, Joseph R. Stock, William J. Lennox et al. · Journal of Medicinal Chemistry · 2007 · 57 citations · Full text

Neuropsychology, Drug Target, Psychopharmacology +19