Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer’s Disease

Robert Martone, Hua Zhou, Kevin Atchison, +33

Journal of Pharmacology and Experimental Therapeutics

WAY-163909 [(7 bR,10 aR)-1,2,3,4,8,9,10,10 a-Octahydro-7 bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A Novel 5-Hydroxytryptamine 2C Receptor-Selective Agonist with Preclinical Antipsychotic-Like Activity

Karen L. Marquis, Annmarie L. Sabb, Sheree F. Logue, +12

Journal of Pharmacology and Experimental Therapeutics

NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations

John H. Kehne, Timothy C. McCloskey, Bruce M. Baron, +4

European Journal of Pharmacology

Potential Anxiolytic EffectsMedicineMechanism Of ActionNeuropharmacologyNeuroscience +4

Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1 <i>H</i> -pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid) _A Receptor

Gabriel Martinez Botella, Francesco G. Salituro, Boyd L. Harrison, +12

Journal of Medicinal Chemistry

Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Scott C. Mayer, Anthony F. Kreft, Boyd L. Harrison, +43

Journal of Medicinal Chemistry

Stable Analogue 10Alzheimer ’Social SciencesNeuroinflammationAlzheimer's Disease +17

Acylguanidines as Small-Molecule β-Secretase Inhibitors

Derek C. Cole, Eric S. Manas, Joseph R. Stock, +23

Journal of Medicinal Chemistry

Protein AssemblyMolecular BiologyAmyloid Precursor ProteinChemical BiologyPharmaceutical Chemistry +18

WAY-163909 [(7 bR, 10 aR)-1,2,3,4,8,9,10,10 a-Octahydro-7 bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a Novel 5-Hydroxytryptamine 2C Receptor-Selective Agonist with Anorectic Activity

John Dunlop, Annmarie L. Sabb, Hossein Mazandarani, +9

Journal of Pharmacology and Experimental Therapeutics

Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503

Sharon Rosenzweig‐Lipson, Jean Zhang, Hossein Mazandarani, +7

Brain Research

Molecular PharmacologyFunctional SelectivityMedicinePhysiologyReceptor (Biochemistry) +5

3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the NMDA (N-methyl-D-aspartic acid) receptor associated glycine binding site

Francesco G. Salituro, Boyd L. Harrison, Bruce M. Baron, +5

Journal of Medicinal Chemistry

Medicinal ChemistryIndole RingBiochemistryFunctional SelectivityMedicine +13

Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors

Michael S. Malamas, Yike Ni, James Erdei, +20

Journal of Medicinal Chemistry

Medicinal ChemistryDrug TargetPharmaceutical ScienceBiochemistryMedicine +13