Concepedia

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

Mei-Chu Lo, Ann Aulabaugh, Guixian Jin, Rebecca Cowling, Jonathan Bard, Michael S. Malamas, George A. Ellestad

Analytical Biochemistry · 2004 · 685 citations · 13 references

DOI

Concepts

References

13

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

, , +17

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

Thomas Wiseman, Samuel Williston, John F. Brandts et al. · Analytical Biochemistry · 1989 · 2.7K citations

, , +14

High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery

Michael W. Pantoliano, Eugene C. Petrella, Joseph D. Kwasnoski et al. · SLAS DISCOVERY · 2001 · 885 citations · Full text

, , +15

Biochemical Applications of Differential Scanning Calorimetry

Julian M. Sturtevant · Annual Review of Physical Chemistry · 1987 · 596 citations

, , +14

Exact Analysis of Competition Ligand Binding by Displacement Isothermal Titration Calorimetry

Bent W. Sigurskjold · Analytical Biochemistry · 2000 · 369 citations

, , +16