Concepedia

Binding Affinity Assessment

Binding Affinity Assessment is a methodological framework in fragment-based drug design that quantifies the strength and specificity of non-covalent interactions between a small molecule fragment and its biological target to distinguish potential lead compounds based on their thermodynamic binding energetics.

1.1K

Publications

58.8K

Citations

5.3K

Authors

1.4K

Institutions

Publications per year

2017–2026

234

Parents

Publications

1.1K

Further Characterization of Specific Drug Binding Sites on Human Serum Albumin

Gillian Sudlow, D. J. Birkett, D. N. Wade · Molecular Pharmacology · 1976 · 1.4K citations

, , +10

Inhibition of the HIV-1 protease by fullerene derivatives: model building studies and experimental verification

Simon H. Friedman, Dianne L. DeCamp, Rint P. Sijbesma et al. · Journal of the American Chemical Society · 1993 · 951 citations

, , +9

A practical computer-based approach to the analysis of radioligand binding experiments

Grant A. McPherson · Computer Programs in Biomedicine · 1983 · 832 citations

, , +10

The Design of Leadlike Combinatorial Libraries

Simon J. Teague, A. M. Davis, Paul D. Leeson et al. · Angewandte Chemie International Edition · 1999 · 810 citations

, , +17

The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands

R. Blair · Toxicological Sciences · 2000 · 799 citations

, , +17

1–5 of 1.1K

Authors

5.3K

  1. AK
    Ahmed Kamal

    Indian Institute of Chemical Technology, India

    6 publications · 264 citations

    6

    h-index

  2. RG
    Ronald Gust

    Freie Universität Berlin, Germany

    6 publications · 179 citations

    6

    h-index

  3. OM
    Ovanes Mekenyan

    Prof. Assen Zlatarov University, Bulgaria

    6 publications · 183 citations

    6

    h-index

  4. JA
    John A. Hartley

    University College London, United Kingdom

    5 publications · 241 citations

    5

    h-index

  5. ML
    María L. López-Rodrı́guez

    Universidad Complutense de Madrid, Spain

    5 publications · 166 citations

    5

    h-index

1–5 of 5.3K

Institutions

1.4K

  1. Chinese Academy of Sciences

    Beijing, China

    14 h-index

    51 publications

    4.8K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    13 h-index

    59 publications

    2.9K citations

  3. National Institutes of Health

    Bethesda, United States

    12 h-index

    60 publications

    2.2K citations

  4. King Saud University

    Riyadh, Saudi Arabia

    12 h-index

    31 publications

    1.2K citations

  5. Freie Universität Berlin

    Berlin, Germany

    12 h-index

    40 publications

    1.7K citations

  6. Indian Institute of Chemical Technology

    Hyderabad, India

    11 h-index

    47 publications

    2.6K citations

  7. Uppsala University

    Uppsala, Sweden

    10 h-index

    39 publications

    5.6K citations

  8. Inserm

    Paris, France

    10 h-index

    26 publications

    1.5K citations

1–8 of 1.4K

Venues

  1. Journal of Medicinal Chemistry

    94 publications · 6K citations

    45

    h-index

  2. Journal of the American Chemical Society

    JACS · 27 publications · 3.6K citations

    24

    h-index

  3. Journal of Chemical Information and Modeling

    JCIM · 31 publications · 2.1K citations

    20

    h-index

  4. PubMed

    Repository · 31 publications · 2K citations

    19

    h-index

  5. Biochemistry

    22 publications · 975 citations

    19

    h-index

1–5