A practical computer-based approach to the analysis of radioligand binding experiments

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

George Scatchard · Annals of the New York Academy of Sciences · 1949 · 19.9K citations

Natural Sciences, Biophysics, Chemistry +9

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

Peter J. Munson, David Rodbard · Analytical Biochemistry · 1980 · 8.5K citations

Life Sciences, Chemistry, Biomolecular Modeling +11

PHARMACOLOGICAL ESTIMATION OF DRUG-RECEPTOR DISSOCIATION CONSTANTS. STATISTICAL EVALUATION. I. AGONISTS

Robert B. Parker, D. R. Waud · Journal of Pharmacology and Experimental Therapeutics · 1971 · 446 citations

Medicine, Pharmacology, Experimental Pharmacology +13

Scatchard plot: Common misinterpretation of binding experiments

Jens G. Nørby, P Ottolenghi, Jörgen Jensen · Analytical Biochemistry · 1980 · 170 citations

Pharmacy, Chemistry, Molecular Biophysics +10