Concepedia

Binding Affinity

Binding Affinity is a thermodynamic parameter that quantifies the strength of a reversible molecular recognition interaction between binding partners at equilibrium, typically expressed as an association (Kₐ) or dissociation (K_d) constant derived from the equilibrium distribution or kinetic rates of the bound and unbound species.

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2017–2026

214

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2.1K

Substituent Constants for Correlation Analysis in Chemistry and Biology.

Gordon L. Flynn · Journal of Pharmaceutical Sciences · 1980 · 2.8K citations

, , +12

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

Thomas Wiseman, Samuel Williston, John F. Brandts et al. · Analytical Biochemistry · 1989 · 2.7K citations

, , +14

Structural Basis of the Drug-binding Specificity of Human Serum Albumin

J. Ghuman, Patricia A. Zunszain, I. Petitpas et al. · Journal of Molecular Biology · 2005 · 1.9K citations

, , +12

Binding constants: The measurement of molecular complex stability

European Journal of Medicinal Chemistry · 1987 · 1.8K citations

, , +12

Binding energies in atomic negative ions

H. Hotop, W. C. Lineberger · Journal of Physical and Chemical Reference Data · 1975 · 1.5K citations

, , +9

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  1. MK
    Michael K. Gilson

    University of California San Diego, United States

    13 publications · 1.6K citations

    13

    h-index

  2. DS
    David S. Hage

    University of Nebraska–Lincoln, United States

    11 publications · 495 citations

    11

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  3. RB
    Rolf Brodersen

    Aarhus University, Denmark

    10 publications · 294 citations

    10

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  4. DJ
    Donald J. Winzor

    The University of Queensland, Australia

    10 publications · 385 citations

    10

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  5. EF
    Ernesto Freire

    Johns Hopkins University, United States

    9 publications · 1.1K citations

    9

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1.5K

  1. National Institutes of Health

    Bethesda, United States

    22 h-index

    64 publications

    5.4K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    21 h-index

    118 publications

    4.7K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    18 h-index

    54 publications

    6.3K citations

  4. Johns Hopkins University

    Baltimore, United States

    18 h-index

    57 publications

    4.7K citations

  5. Harvard University

    Cambridge, United States

    18 h-index

    52 publications

    6.4K citations

  6. Inserm

    Paris, France

    16 h-index

    81 publications

    3.4K citations

  7. University of California San Diego

    San Diego, United States

    16 h-index

    41 publications

    2.6K citations

  8. Aarhus University

    Aarhus, Denmark

    16 h-index

    51 publications

    3.3K citations

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  1. Journal of the American Chemical Society

    JACS · 145 publications · 16.8K citations

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  2. Biochemistry

    203 publications · 13.6K citations

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  3. Journal of Biological Chemistry

    JBC · 82 publications · 4.7K citations

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  4. The Journal of Physical Chemistry

    61 publications · 3.4K citations

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  5. Journal of Molecular Biology

    JMB · 33 publications · 4.4K citations

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