Concepedia

Hit Validation

Hit Validation is the experimental confirmation process within screening assays that distinguishes genuine bioactive compounds from false positives by applying rigorous secondary assays and analytical criteria to initial screening hits.

53

Publications

4.4K

Citations

437

Authors

136

Institutions

Publications per year

2017–2026

21

Parents

Publications

53

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

Mei-Chu Lo, Ann Aulabaugh, Guixian Jin et al. · Analytical Biochemistry · 2004 · 685 citations

, , +14

Validation of the Headache Impact Test (HIT-6™) across episodic and chronic migraine

Min Yang, Regina Rendas‐Baum, Sepideh F. Varon et al. · Cephalalgia · 2010 · 546 citations · Full text

, , +16

The Smart City as Global Discourse: Storylines and Critical Junctures across 27 Cities

Simon Joss, Frans Sengers, Daan Schraven et al. · Journal of Urban Technology · 2019 · 431 citations · Full text

, , +14

Novel Inhibitors of DNA Gyrase:  3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening

Hans-Joachim Boehm, Markus Boehringer, Daniel Bur et al. · Journal of Medicinal Chemistry · 2000 · 379 citations

, , +16

Reactive compounds and in vitro false positives in HTS

Gilbert M. Rishton · Drug Discovery Today · 1997 · 354 citations

, , +5

1–5 of 53

Authors

437

  1. JZ
    Ji-Hu Zhang

    Novartis (United States), United States

    3 publications · 130 citations

    3

    h-index

  2. RW
    Robert Wawrzinek

    The University of Queensland, Australia

    2 publications · 81 citations

    2

    h-index

  3. ER
    Eugene R. Hickey

    Boehringer Ingelheim (United States), United States

    2 publications · 82 citations

    2

    h-index

  4. JA
    Jonas Aretz

    Max Planck Institute of Colloids and Interfaces, Germany

    2 publications · 81 citations

    2

    h-index

  5. MW
    Mao Wang

    National Heart Centre Singapore, Singapore

    2 publications · 82 citations

    2

    h-index

1–5 of 437

Institutions

136

  1. Novartis (Switzerland)

    Basel, Switzerland

    4 h-index

    18 publications

    355 citations

  2. University of Washington

    Seattle, United States

    3 h-index

    10 publications

    416 citations

  3. ETH Zurich

    Zurich, Switzerland

    2 h-index

    6 publications

    198 citations

  4. Boehringer Ingelheim (Germany)

    Ingelheim, Germany

    2 h-index

    3 publications

    40 citations

  5. Novartis (United States)

    New York, United States

    2 h-index

    10 publications

    305 citations

  6. Freie Universität Berlin

    Berlin, Germany

    2 h-index

    12 publications

    486 citations

  7. Max Planck Institute of Colloids and Interfaces

    Potsdam, Germany

    2 h-index

    13 publications

    539 citations

  8. Novartis (China)

    Beijing, China

    2 h-index

    10 publications

    138 citations

1–8 of 136

Venues

  1. Journal of Medicinal Chemistry

    10 publications · 795 citations

    10

    h-index

  2. SLAS DISCOVERY

    4 publications · 89 citations

    4

    h-index

  3. ACS Medicinal Chemistry Letters

    3 publications · 111 citations

    3

    h-index

  4. ChemMedChem

    3 publications · 158 citations

    3

    h-index

  5. Angewandte Chemie International Edition

    2 publications · 86 citations

    2

    h-index

1–5