Concepedia

Lead Discovery

Lead Discovery is a systematic research process within drug design that identifies and optimizes bioactive compounds with desirable pharmacological properties, distinguishing it from related processes by its focus on the initial identification of hit compounds suitable for further development into drug candidates.

3.6K

Publications

201.2K

Citations

23.8K

Authors

3.1K

Institutions

Publications per year

2017–2026

1.1K

Parents

Children

Publications

3.6K

Lead- and drug-like compounds: the rule-of-five revolution

Christopher A. Lipinski · Drug Discovery Today Technologies · 2004 · 6.1K citations

, , +14

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

Jonathan B. Baell, Georgina A. Holloway · Journal of Medicinal Chemistry · 2010 · 3.9K citations

, , +14

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

Stephen D. Roughley, Allan M. Jordan · Journal of Medicinal Chemistry · 2011 · 2.7K citations

, , +7

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Wenhao Dai, Bing Zhang, Xia-Ming Jiang et al. · Science · 2020 · 1.6K citations · Full text

, , +17

Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

Elizabeth A. Ilardi, Edon Vitaku, Jón T. Njardarson · Journal of Medicinal Chemistry · 2013 · 1.6K citations

, , +12

1–5 of 3.6K

Authors

23.8K

  1. JB
    Jonathan B. Baell

    Monash University, Australia

    14 publications · 5.8K citations

    14

    h-index

  2. MK
    Marcel Kaiser

    Swiss Tropical and Public Health Institute, Switzerland

    15 publications · 689 citations

    14

    h-index

  3. GS
    Gisbert Schneider

    ETH Zurich, Switzerland

    15 publications · 688 citations

    14

    h-index

  4. JB
    Jürgen Bajorath

    University of Bonn, Germany

    16 publications · 552 citations

    14

    h-index

  5. JN
    Jeremy N. Burrows

    Medicines for Malaria Venture, Switzerland

    13 publications · 1K citations

    13

    h-index

1–5 of 23.8K

Institutions

3.1K

  1. Pfizer (United States)

    New York, United States

    32 h-index

    551 publications

    29.5K citations

  2. Chinese Academy of Sciences

    Beijing, China

    32 h-index

    492 publications

    47.8K citations

  3. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    32 h-index

    361 publications

    26.6K citations

  4. University of California San Diego

    San Diego, United States

    31 h-index

    151 publications

    17.4K citations

  5. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    29 h-index

    688 publications

    26.6K citations

  6. National Institutes of Health

    Bethesda, United States

    28 h-index

    171 publications

    14.7K citations

  7. University of California, San Francisco

    San Francisco, United States

    28 h-index

    204 publications

    19.4K citations

  8. GlaxoSmithKline (United Kingdom)

    London, United Kingdom

    27 h-index

    212 publications

    12.2K citations

1–8 of 3.1K

Venues

  1. Journal of Medicinal Chemistry

    596 publications · 51.9K citations

    105

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    281 publications · 8.9K citations

    46

    h-index

  3. Bioorganic & Medicinal Chemistry

    113 publications · 4K citations

    39

    h-index

  4. ACS Medicinal Chemistry Letters

    94 publications · 3.9K citations

    35

    h-index

  5. Journal of Chemical Information and Modeling

    JCIM · 89 publications · 3.8K citations

    34

    h-index

1–5