Concepedia

Macrocycle Discovery

Macrocycle Discovery is a methodological approach within lead discovery that identifies large-ring compounds through systematic exploration of chemical space to enhance binding affinity and selectivity toward biological targets.

351

Publications

14.4K

Citations

1.8K

Authors

440

Institutions

Publications per year

2017–2026

79

Parents

Publications

351

Carbon Networks Based on Dehydrobenzoannulenes: Synthesis of Graphdiyne Substructures

Michael M. Haley, Stephen C. Brand, Joshua J. Pak · Angewandte Chemie International Edition in English · 1997 · 486 citations

, , +8

Pure CH Hydrogen Bonding to Chloride Ions: A Preorganized and Rigid Macrocyclic Receptor

Yongjun Li, Amar H. Flood · Angewandte Chemie International Edition · 2008 · 452 citations

, , +17

Comprehensive analysis of loops at protein-protein interfaces for macrocycle design

Jason Gavenonis, Bradley A Sheneman, Timothy R. Siegert et al. · Nature Chemical Biology · 2014 · 200 citations · Full text

, , +16

Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules

Dmitry L. Usanov, Alix I Chan, Juan Pablo Maianti et al. · Nature Chemistry · 2018 · 192 citations · Full text

, , +14

“[12]Mercuracarborand‐4”, the First Representative of a New Class of Rigid Macrocyclic Electrophiles: The Chloride Ion Complex of a Charge‐Reversed Analogue of [12]Crown‐4

Xiaoguang Yang, Carolyn B. Knobler, M. Frederick Hawthorne · Angewandte Chemie International Edition in English · 1991 · 175 citations

, , +14

1–5 of 351

Authors

1.8K

  1. LF
    Leonard F. Lindoy

    The University of Sydney, Australia

    7 publications · 270 citations

    7

    h-index

  2. MM
    Mary McPartlin

    London Metropolitan University, United Kingdom

    5 publications · 123 citations

    5

    h-index

  3. RR
    Ruth R. Wexler

    Bristol-Myers Squibb (United States), United States

    4 publications · 148 citations

    4

    h-index

  4. MG
    Mothukuri Ganesh Kumar

    Indian Institute of Science Education and Research Pune, India

    4 publications · 123 citations

    4

    h-index

  5. CH
    Christian Heinis

    École Polytechnique Fédérale de Lausanne, Switzerland

    4 publications · 123 citations

    4

    h-index

1–5 of 1.8K

Institutions

440

  1. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    40 publications

    1.1K citations

  2. The University of Sydney

    Sydney, Australia

    6 h-index

    20 publications

    732 citations

  3. Tohoku University

    Sendai, Japan

    5 h-index

    20 publications

    699 citations

  4. University of Groningen

    Groningen, The Netherlands

    5 h-index

    19 publications

    972 citations

  5. Bristol-Myers Squibb (United States)

    New York, United States

    5 h-index

    74 publications

    3.2K citations

  6. University of California, Los Angeles

    Los Angeles, United States

    5 h-index

    15 publications

    822 citations

  7. Scripps Research Institute

    San Diego, United States

    5 h-index

    11 publications

    748 citations

  8. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    5 h-index

    42 publications

    1.3K citations

1–8 of 440

Venues

  1. Organic Letters

    OL · 29 publications · 1K citations

    21

    h-index

  2. Angewandte Chemie International Edition

    22 publications · 1.4K citations

    19

    h-index

  3. Journal of the American Chemical Society

    JACS · 19 publications · 1.5K citations

    17

    h-index

  4. Journal of Medicinal Chemistry

    15 publications · 621 citations

    15

    h-index

  5. Chemical Communications

    ChemComm · 15 publications · 530 citations

    14

    h-index

1–5