Stephen D. Roughley

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

Stephen D. Roughley, Allan M. Jordan · Journal of Medicinal Chemistry · 2011 · 2.7K citations

Pharmacy, Medicinal Chemistry, Oncology +7

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

Paul A. Brough, Wynne Aherne, Xavier Barril et al. · Journal of Medicinal Chemistry · 2007 · 445 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design

Brian Dymock, Xavier Barril, Paul A. Brough et al. · Journal of Medicinal Chemistry · 2005 · 231 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-<i>d</i>]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone

Paul A. Brough, Xavier Barril, Jenifer Borgognoni et al. · Journal of Medicinal Chemistry · 2009 · 173 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Drug-like Annotation and Duplicate Analysis of a 23-Supplier Chemical Database Totalling 2.7 Million Compounds

Nicolas Baurin, Ruth L. Baker, C. E. Richardson et al. · Journal of Chemical Information and Computer Sciences · 2004 · 115 citations

Pharmacy, Medicinal Chemistry, Drug Design +15