Iain Cumming

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

Scott Boyd, Joanna Brookfield, Susan E. Critchlow et al. · Journal of Medicinal Chemistry · 2015 · 92 citations · Full text

Drug Target, Selective Inhibitors, Chemical Biology +18

Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines

Sébastien L. Degorce, Michael S. Bodnarchuk, Iain Cumming et al. · Journal of Medicinal Chemistry · 2018 · 86 citations · Full text

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2020 · 80 citations · Full text

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2022 · 56 citations · Full text

A novel series of positive modulators of the AMPA receptor: Discovery and structure based hit-to-lead studies

Craig Jamieson, Stephanie Basten, Robert A. Campbell et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 36 citations · Full text

Signal Transduction, Molecular Physiology, Biochemistry +13