Joanna Brookfield

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

Scott Boyd, Joanna Brookfield, Susan E. Critchlow et al. · Journal of Medicinal Chemistry · 2015 · 92 citations · Full text

Drug Target, Selective Inhibitors, Chemical Biology +18

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

Katerina Mardilovich, Mark Baugh, Diane Crighton et al. · Oncotarget · 2015 · 48 citations · Full text

Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models

M. Raymond V. Finlay, Mark J. Anderton, Andrew Bailey et al. · Journal of Medicinal Chemistry · 2019 · 29 citations · Full text

Oral Bioavailability, Pharmacotherapy, Gls1 Inhibitor Bis-2- +16

Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs)

Nick Bailey, Mark J. Bamford, Delphine Brissy et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 16 citations · Full text

Medicinal Chemistry, Active C-6 Heteroaryl-, Medicine +3

Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties

Mark Charles, Joanna Brookfield, Tennyson Ekwuru et al. · Journal of Medicinal Chemistry · 2015 · 16 citations · Full text

Drug Target, High Throughput, Pharmacotherapy +16