Tennyson Ekwuru

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

Diana Zatreanu, Helen M.R. Robinson, Omar Alkhatib et al. · Nature Communications · 2021 · 350 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta

Martin L. Stockley, Amanda Ferdinand, Giovanni Benedetti et al. · Journal of Medicinal Chemistry · 2022 · 43 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models

M. Raymond V. Finlay, Mark J. Anderton, Andrew Bailey et al. · Journal of Medicinal Chemistry · 2019 · 29 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties

Mark Charles, Joanna Brookfield, Tennyson Ekwuru et al. · Journal of Medicinal Chemistry · 2015 · 17 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11