Mark Charles

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

Diana Zatreanu, Helen M.R. Robinson, Omar Alkhatib et al. · Nature Communications · 2021 · 336 citations · Full text

A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth <i>In vitro</i> and <i>In vivo</i>

Kuzhuvelil B. Harikumar, Ajaikumar B. Kunnumakkara, Nobuo Ochi et al. · Molecular Cancer Therapeutics · 2010 · 170 citations · Full text

Identifying strategies to target the metabolic flexibility of tumours

Andrés Méndez‐Lucas, Wei Lin, Paul C. Driscoll et al. · Nature Metabolism · 2020 · 140 citations · Full text

Metabolic Remodeling, Metabolic Pathway Analysis, Metabolic Flexibility +5

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

Katerina Mardilovich, Mark Baugh, Diane Crighton et al. · Oncotarget · 2015 · 48 citations · Full text

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

Ian Evans, Azadeh Bagherzadeh, Mark Charles et al. · Biochemical Journal · 2010 · 44 citations · Full text

Endothelial Cells, Cellular Physiology, Molecular Pharmacology +17