Sue Bickerton

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2020 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2022 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17

Osimertinib, an Irreversible Next-Generation EGFR Tyrosine Kinase Inhibitor, Exerts Antitumor Activity in Various Preclinical NSCLC Models Harboring the Uncommon EGFR Mutations G719X or L861Q or S768I

Nicolas Floc’h, Sangbin Lim, Sue Bickerton et al. · Molecular Cancer Therapeutics · 2020 · 49 citations · Full text

Medicine, Oncology, Pharmacology +17

Evaluation of Novel Renal Biomarkers with a Cisplatin Model of Kidney Injury: Gender and Dosage Differences

Mark Pinches, Catherine J. Betts, Sue Bickerton et al. · Toxicologic Pathology · 2012 · 47 citations

Medicine, Pharmacology, Toxicology +16

Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance

M. Raymond V. Finlay, Peter Barton, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2021 · 32 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15