Jason G. Kettle

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Adriana E. Tron, Matthew A. Belmonte, Ammar Adam et al. · Nature Communications · 2018 · 479 citations · Full text

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

Jason G. Kettle, Husam Alwan, Michał Biśta et al. · Journal of Medicinal Chemistry · 2016 · 135 citations · Full text

Tool Compounds, Chemoprevention Strategy, Selective Inhibitors +18

Synthesis of brevetoxin sub-units by sequential ring-closing metathesis and hydroboration

J. Stephen Clark, Jason G. Kettle · Tetrahedron Letters · 1997 · 131 citations

Halogenation, Engineering, Biochemistry +6

Enantioselective synthesis of medium-ring sub-units of brevetoxin A by ring-closing metathesis

J. Stephen Clark, Jason G. Kettle · Tetrahedron Letters · 1997 · 122 citations

Halogenation, Engineering, Ring-closing Metathesis +6

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Jon Winter, Malcolm Anderson, Kevin Blades et al. · Journal of Medicinal Chemistry · 2015 · 118 citations

Protein Assembly, Molecular Biology, Chemical Biology +20