Jon Winter

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Richard A. Ward, C. Brassington, Alexander L. Breeze et al. · Journal of Medicinal Chemistry · 2012 · 169 citations · Full text

Aldo-keto Reductase, Molecular Biology, Lead Identification +19

Directed Dihydroxylation of Cyclic Allylic Alcohols and Trichloroacetamides Using OsO₄/TMEDA

Timothy J. Donohoe, Kevin Blades, Peter R. Moore et al. · The Journal of Organic Chemistry · 2002 · 138 citations

Cross-coupling Reaction, Bioorganic Chemistry, Biochemistry +9

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Jon Winter, Malcolm Anderson, Kevin Blades et al. · Journal of Medicinal Chemistry · 2015 · 118 citations

Protein Assembly, Molecular Biology, Chemical Biology +20

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

Scott Boyd, Joanna Brookfield, Susan E. Critchlow et al. · Journal of Medicinal Chemistry · 2015 · 92 citations · Full text

Drug Target, Selective Inhibitors, Chemical Biology +18

Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation

Michael J. Waring, David Andrews, Paul Faulder et al. · Chemical Communications · 2013 · 34 citations

Type Iii Phosphatidylinositol-4-kinase, Cancer Cell Proliferation, Cellular Pharmacology +17