C. Brassington

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Richard A. Ward, C. Brassington, Alexander L. Breeze et al. · Journal of Medicinal Chemistry · 2012 · 169 citations · Full text

Aldo-keto Reductase, Molecular Biology, Lead Identification +19

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Jon Winter, Malcolm Anderson, Kevin Blades et al. · Journal of Medicinal Chemistry · 2015 · 118 citations

Protein Assembly, Molecular Biology, Chemical Biology +20

Structural basis of Lewis ^b antigen binding by the <i>Helicobacter pylori</i> adhesin BabA

Naim Hage, Tina Howard, Chris Phillips et al. · Science Advances · 2015 · 83 citations · Full text

Crystal Structure, Protein Assembly, Biochemistry +13

Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives

Julie A. Tucker, Neil Bennett, C. Brassington et al. · PLoS ONE · 2012 · 55 citations · Full text

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis

Anna A. Marusiak, Natalie L. Stephenson, Hayeon Baik et al. · Cancer Research · 2015 · 47 citations · Full text