Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent

Kevin M. Foote, J. Willem M. Nissink, Thomas M. McGuire, +11

Journal of Medicinal Chemistry

Kinase Ataxia TelangiectasiaCell DeathMolecular BiologyPharmacotherapyCompound 2 +17

Discovery of 4-{4-[(3<i>R</i>)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1<i>H</i>-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

Kevin M. Foote, Kevin Blades, Anna Cronin, +16

Journal of Medicinal Chemistry

Compound 6PharmacotherapyPharmaceutical ChemistryTumor BiologyMedicinal Chemistry +15

Directed Dihydroxylation of Cyclic Allylic Alcohols and Trichloroacetamides Using OsO₄/TMEDA

Timothy J. Donohoe, Kevin Blades, Peter R. Moore, +5

The Journal of Organic Chemistry

Cross-coupling ReactionBioorganic ChemistryBiochemistryNatural SciencesCyclic Allylic Alcohols +7

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Jon Winter, Malcolm Anderson, Kevin Blades, +16

Journal of Medicinal Chemistry

Protein AssemblyMolecular BiologyChemical BiologySos ComplexSmall Molecule Binding +18

Discovery of Pyrazolo[1,5-<i>a</i>]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

William McCoull, Roman Abrams, Erica Anderson, +31

Journal of Medicinal Chemistry

Directed Dihydroxylation of Allylic Trichloroacetamides

Timothy J. Donohoe, Kevin Blades, Madeleine Helliwell, +3

The Journal of Organic Chemistry

Medicinal ChemistryEnantioselective SynthesisCross-coupling ReactionBiochemistryNatural Sciences +8

The synthesis of (+)-pericosine B

Timothy J. Donohoe, Kevin Blades, Madeleine Helliwell, +2

Tetrahedron Letters

Bioorganic Chemistry-Pericosine BNatural Product SynthesisSynthetic ChemistryBiomolecular Engineering

The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing

Clifford D. Jones, David Andrews, Andrew Barker, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceHealth SciencesPotent Imidazole PyrimidineMedicine +10

A reproducible and high-yielding cerium-mediated route to α,α-difluoro-β-ketophosphonates

Kevin Blades, Thierry Lequeux, Jonathan M. Percy

Tetrahedron

Organic ChemistryFluorous SynthesisChemistryHigh-yielding Cerium-mediated Route

Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors

Clifford D. Jones, David Andrews, Andrew Barker, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +9