SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors

Nicola M. Heron, Malcolm Anderson, David P. Blowers, +13

Bioorganic & Medicinal Chemistry Letters

Molecular DockingMedicineNatural SciencesReceptor Tyrosine KinaseRational Drug Design +7

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Jon Winter, Malcolm Anderson, Kevin Blades, +16

Journal of Medicinal Chemistry

Protein AssemblyMolecular BiologyChemical BiologySos ComplexSmall Molecule Binding +18

Imidazo[1,2-a]pyridines: A potent and selective class of cyclin-Dependent kinase inhibitors identified through structure-Based hybridisation

Malcolm Anderson, John F. Beattie, Gloria A. Breault, +11

Bioorganic & Medicinal Chemistry Letters

Cyclin-dependent Kinase InhibitorsMedicinal ChemistryBioorganic ChemistryHeterocyclicBiochemistry +8

Enhanced Detection of Low-Abundance Host Cell Protein Impurities in High-Purity Monoclonal Antibodies Down to 1 ppm Using Ion Mobility Mass Spectrometry Coupled with Multidimensional Liquid Chromatography

Catalin E. Doneanu, Malcolm Anderson, Brad J. Williams, +3

Analytical Chemistry

Hcps PresentImmunologyBiological Mass SpectrometryMolecular BiologyProtein Purification +20

Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: Matching high information content with high throughput

Geoffrey A. Holdgate, Malcolm Anderson, Fredrik Edfeldt, +1

Journal of Structural Biology

Molecular DockingRecombinant ProteinsBiochemistryProtein FoldingMedicine +11

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

Darragh P. O’Brien, Hannah B. L. Jones, Franziska Guenther, +9

Molecular & Cellular Proteomics

Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors

Malcolm Anderson, David Andrews, Andy Barker, +19

Bioorganic & Medicinal Chemistry Letters

Cyclin-dependent Kinase InhibitorsMedicinal ChemistryDrug TargetBiochemistryPotent Class +11

Engineering a High-Affinity Anti-IL-15 Antibody: Crystal Structure Reveals an α-Helix in VH CDR3 as Key Component of Paratope

David C. Lowe, S. Gerhardt, Alison Ward, +12

Journal of Molecular Biology

Crystal StructureVh Cdr3ImmunologyTumor ImmunityMolecular Biology +10

Refolding, Purification, and Characterization of a Loop Deletion Mutant of Human Bcl-2 from Bacterial Inclusion Bodies

Malcolm Anderson, David P. Blowers, Neil Hewitt, +4

Protein Expression and Purification

PathogenesisBacteriologyMolecular BiologyMicrobiologyMolecular Microbiology +4

E. coli expression and purification of human and cynomolgus IL-15

Alison Ward, Malcolm Anderson, Robert I. Craggs, +7

Protein Expression and Purification

CytokineProtein ExpressionMicrobial PathogensE. Coli ExpressionImmunology +3