Fredrik Edfeldt

Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: Matching high information content with high throughput

Geoffrey A. Holdgate, Malcolm Anderson, Fredrik Edfeldt et al. · Journal of Structural Biology · 2010 · 61 citations

Molecular Docking, Recombinant Proteins, Biochemistry +13

HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase

Johan Evenäs, Fredrik Edfeldt, Matti Lepistö et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 33 citations · Full text

Pharmaceutical Science, Pharmaceutical Chemistry, Biochemistry +11

Hot-Spotting with Thermal Scanning: A Ligand- and Structure-Independent Assessment of Target Ligandability

Molly Chilton, Benjamin Clennell, Fredrik Edfeldt et al. · Journal of Medicinal Chemistry · 2017 · 19 citations

Engineering, Protein Target, Molecular Biology +18

Fragment-Based Discovery of Novel Allosteric MEK1 Binders

Paolo Di Fruscia, Fredrik Edfeldt, Igor L. Shamovsky et al. · ACS Medicinal Chemistry Letters · 2021 · 16 citations · Full text

Drug Target, Mek1 Kinase, Engineering +21

Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)

Fredrik Edfeldt, Johan Evenäs, Matti Lepistö et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 15 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +4