Paolo Di Fruscia

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

Barrie Peck, Chun‐Yuan Chen, Ka-Kei Ho et al. · Molecular Cancer Therapeutics · 2010 · 434 citations

Medicine, Oncology, Pharmacology +17

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-<i>N</i>-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Jeffrey W. Johannes, Amber Balazs, Derek Barratt et al. · Journal of Medicinal Chemistry · 2021 · 140 citations · Full text

Life Sciences, Medicinal Chemistry, Oncology +13

The Discovery of a Highly Selective 5,6,7,8‐Tetrahydrobenzo[4,5]thieno[2,3‐<i>d</i>]pyrimidin‐4(3<i>H</i>)‐one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model

Paolo Di Fruscia, Emmanouil Zacharioudakis, Chang Liu et al. · ChemMedChem · 2014 · 73 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket

Sandeep Sundriyal, S. Moniot, Zimam Mahmud et al. · Journal of Medicinal Chemistry · 2017 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel

Nicoletta Pedemonte, Fabio Bertozzi, Emanuela Caci et al. · Science Advances · 2020 · 48 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17