Derek Barratt - Concepedia

Concepedia

Author

Derek Barratt

AstraZeneca (United Kingdom)

Also Known As

B. Williamson, D Barratt, D G Barratt, D. Barratt, D. G. Barratt, D.G. Barratt, Derek Barratt, Derek G. Barratt

34

Publications

1.5K

Citations

14

H-Index

30

Concepts

All Affiliations

AstraZeneca (United Kingdom)AstraZeneca (United States)AstraZeneca (Sweden)AstraZeneca (Poland)

DB

About

Derek Barratt is an author at AstraZeneca (United Kingdom) specializing in medicine, natural sciences, and pharmacology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	5	5	870
2	Natural Sciences	4	4	409
3	Biochemistry	4	4	169
4	Engineering	1	1	23
5	Biomolecular Engineering	1	1	77

Derek Barratt

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15

Publications

1.5K

Citations

13

H-Index

	Year	Citations
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor Vanessa Rodrik-Outmezguine, Masanori Okaniwa, Zhan Yao, Nature MedicineMtor Resistance MutationsMolecular BiologyResistance Mutation (Virology)Pharmacology	2016	469
Crystal Structure of Human MMP9 in Complex with a Reverse Hydroxamate Inhibitor Siân Rowsell, Paul Hawtin, Claire A. Minshull, Journal of Molecular Biology Crystal StructureHuman Mmp9MedicineNatural SciencesMetalloprotein	2002	255
Hydrogen bonding. Part 9. Solute proton donor and proton acceptor scales for use in drug design Michael H. Abraham, Philip P. Duce, David V. Prior, Journal of the Chemical Society Perkin Transactions 2	1989	232
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-<i>N</i>-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs Jeffrey W. Johannes, Amber Balazs, Derek Barratt, Journal of Medicinal Chemistry	2021	129
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-<i>a</i>]pyridin-6-yl)amino]-9-(tetrahydro-2<i>H</i>-pyran-4-yl)-7,9-dihydro-8<i>H</i>-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor Frederick W. Goldberg, M. Raymond V. Finlay, Attilla Ting, Journal of Medicinal Chemistry PharmacotherapyChemical BiologyDna-pk Catalytic SubunitPharmaceutical ChemistryPre-clinical Pharmacology	2019	77
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors Kirsten McAulay, Emily Hoyt, Morgan Thomas, Journal of the American Chemical Society	2020	73
Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase. Alexander L. Breeze, B. V. Kara, Derek Barratt, The EMBO Journal Protein FunctionSignal TransductionBiochemistryNatural SciencesReceptor (Biochemistry)	1996	54
Development of a high‐throughput method for preparing human urine for two‐dimensional electrophoresis Graeme Smith, Derek Barratt, Rachel Rowlinson, PROTEOMICS	2005	49
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS<sup>G12C</sup> with Demonstrable CNS Penetration Jason G. Kettle, Sharan K. Bagal, Derek Barratt, Journal of Medicinal Chemistry	2023	27
Hydrogen bonding. Part 1.—Equilibrium constants and enthalpies of complexation for monomeric carboxylic acids with N-methylpyrrolidinone in 1,1,1-trichloroethane Michael H. Abraham, Philip P. Duce, Ronald A. Schulz, Journal of the Chemical Society Faraday Transactions 1 Physical Chemistry in Condensed Phases Chemical EngineeringEngineeringBiochemistryNatural SciencesChemical Bond	1986	23

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